NPY coordination of energy balance and physical activity

NPY 能量平衡和身体活动的协调

• 批准号: nhmrc : 1123877
• 负责人: Prof Herbert Herzog
• 金额: $ 57.71万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/npy-coordination-energy-physical-activity/947245
• 关键词: NPY; coordination; energy; balance; physical

Anorexia nervosa (AN) is an eating disorder characterized by behavioral alterations, restrictive eating leading to extremely low body weight. AN is also associated with a paradoxical hyperactivity representing a failure of the brain to adjust activity to energy status. Here we aim to investigate the role of the Neuropeptide Y (NPY), a known regulator of homeostatic control and activity in the development of hyperactivity in AN, thus help to identify NPY-targeted therapeutics for AN treatment.

神经性厌食症(AN)是一种以行为改变为特征的饮食障碍，限制进食导致体重极低。AN还与一种矛盾的多动症有关，代表着大脑无法调整活动以适应能量状态。在这里，我们旨在研究神经肽Y(NPY)在AN多动发展中的作用，NPY是已知的平衡控制和活动调节因子，因此有助于确定NPY的靶向治疗方法。