NPY coordination of energy balance and physical activity

NPY 能量平衡和身体活动的协调

• 批准号: nhmrc : GNT1123877
• 负责人: Prof Herbert Herzog
• 金额: $ 84.46万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/npy-coordination-energy-physical-activity/1347371
• 关键词: NPY; coordination; energy; balance; physical

Anorexia nervosa (AN) is an eating disorder characterized by behavioral alterations, restrictive eating leading to extremely low body weight. AN is also associated with a paradoxical hyperactivity representing a failure of the brain to adjust activity to energy status. Here we aim to investigate the role of the Neuropeptide Y (NPY), a known regulator of homeostatic control and activity in the development of hyperactivity in AN, thus help to identify NPY-targeted therapeutics for AN treatment.

神经性厌食症（AN）是一种以行为改变、限制性进食导致体重极低为特征的进食障碍。AN还与反常的多动有关，其表示大脑未能根据能量状态调整活动。在这里，我们的目的是研究神经肽Y（NPY）的作用，一个已知的调节剂的稳态控制和活动的发展中的AN多动症，从而帮助确定神经肽Y靶向治疗AN治疗。