PET STUDY OF CNS BENZODIAZEPINE RECEPTORS IN ADOLESCENT ONSET ALCOHOLISM

青少年酒精中毒中枢神经系统苯二氮卓受体的 PET 研究

• 批准号: 6275838
• 负责人: DUNCAN B. CLARK
• 金额: $ 1.91万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6275838
• 关键词: adolescence (12-20); alcoholic beverage consumption; alcoholism /alcohol abuse; benzodiazepine receptor; central nervous system disorders; clinical research; human subject; neurochemistry; positron emission tomography; receptor expression; receptor sensitivity; toxicant interaction; toxicology

This proposal requests GCRC support to obtain pilot data on the effects of chronic and alcohol consumption on benzodiazepine receptor (BZR) distribution and density in adolescent onset alcohol dependence using [11C] flumazenil binding visualized by PET. Alterations in the GABA neurotransmitter system induced by chronic alcohol consumption represent the most likely neurochemical substrate of alcohol dependence. In two recent imaging studies, alcohol dependence in adults has been found to be associated with reduced BZR density in the cingulate cortex.

该提案要求全球区域中心提供支持，以获得关于 慢性和饮酒对苯二氮卓受体（BZR）的影响 青少年酒精依赖的分布和密度 [11C]通过PET观察氟马西尼结合。GABA的变化 慢性酒精摄入引起的神经递质系统 酒精依赖最可能的神经化学物质在两 最近的成像研究发现，成年人的酒精依赖 与扣带皮层BZR密度降低有关。