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PET STUDY OF CNS BENZODIAZEPINE RECEPTORS IN ADOLESCENT ONSET ALCOHOLISM

PET STUDY OF CNS BENZODIAZEPINE RECEPTORS IN ADOLESCENT ONSET ALCOHOLISM
青少年酒精中毒中枢神经系统苯二氮卓受体的 PET 研究
批准号：
6275838
负责人：
DUNCAN B. CLARK
金额：
$1.91万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-12-01 至 1998-11-30
来源：
https://reporter.nih.gov/project-details/6275838
关键词：
adolescence (12-20) alcoholic beverage consumption alcoholism /alcohol abuse benzodiazepine receptor central nervous system disorders clinical research human subject neurochemistry positron emission tomography receptor expression receptor sensitivity toxicant interaction toxicology

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英文摘要
This proposal requests GCRC support to obtain pilot data on the effects of chronic and alcohol consumption on benzodiazepine receptor (BZR) distribution and density in adolescent onset alcohol dependence using [11C] flumazenil binding visualized by PET. Alterations in the GABA neurotransmitter system induced by chronic alcohol consumption represent the most likely neurochemical substrate of alcohol dependence. In two recent imaging studies, alcohol dependence in adults has been found to be associated with reduced BZR density in the cingulate cortex.
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