National Consortium on Alcohol and NeuroDevelopment in Adolescence:Pittsburgh

国家青少年酒精与神经发育联盟：匹兹堡

• 批准号: 8693887
• 负责人: DUNCAN B. CLARK
• 金额: $ 50.99万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-05 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8693887
• 关键词: Abstinence; Address; Adolescence; Adolescent; Adult; Advanced Development; Adverse effects; Affect; Affective; Age; Alcohol consumption; Alcohol or Other Drugs use; Alcoholic Intoxication; Alcoholism; Alcohols; Anatomy; Area; Behavioral; Behavioral inhibition; Brain; Brain imaging; California; Cerebrum; Characteristics; Childhood; Clinical assessments; Cognitive; Communities; DNA; Data; Development; Diagnostic; Diffusion Magnetic Resonance Imaging; Dose; Drug usage; Family history of; Foundations; Functional Magnetic Resonance Imaging; Future; Goals; Heavy Drinking; Human; Imaging Techniques; International; Laboratories; Longitudinal Studies; Magnetic Resonance Imaging; Measures; Mental Health; Neurobiology; Neurocognitive; Neuropsychological Tests; Outcome; Pattern; Population; Prevention; Protocols documentation; Psychopathology; Recruitment Activity; Regulation; Reporting; Research; Resolution; Rest; Rewards; Risk; Risk Factors; Role; Saccades; Sampling; Site; Sleep; Sleep Architecture; Sleep Stages; Structure; Substance Use Disorder; System; Teenagers; Universities; Visit; adolescent alcohol; alcohol abstinence; alcohol and other drug; alcohol consequences; alcohol effect; alcohol exposure; alcohol use disorder; base; disorder risk; drinking; follow-up; genetic analysis; high risk; longitudinal design; medical specialties; neurodevelopment; neuroimaging; neuropsychological; psychobiologic; psychologic; relating to nervous system; response; sex; twelfth grade; underage drinking; white matter; young adult

DESCRIPTION (provided by applicant): In response to RFA-AA-12-006, this application proposes the Pittsburgh Research Component of the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA: Pittsburgh) to determine the effects of alcohol use on the developing adolescent brain. Recruited at ages 12 through 21, a high risk enhanced community sample of 170 Pittsburgh subjects (N=680 from all sites) will complete a baseline assessment and undergo three annual follow-up assessments in an accelerated longitudinal design. At each visit, a multimodal magnetic resonance imaging (MRI) protocol, comprehensive neuropsychological battery, and assessments of alcohol and other substance use and related problems, mental health symptomatology, and substance use disorder risk factors will be measured. Brain imaging includes state-of-the-art high resolution structural MRI (sMRI), diffusion tensor imaging (DTI), and resting state MRI (rsMRI). The examination of alcohol consequences will focus on structural and functional maturation of brain areas that are actively developing during adolescence, involved in psychological regulation, responsive to rewards, and thought to be vulnerable to toxic alcohol effects. In addition, NCANDA: Pittsburgh will collaborate on two supplemental studies. We will collaborate with NCANDA: Duke in a study utilizing functional MRI to examine cerebral activation during a reward modulated anti-saccade task to study alcohol effects on reward responding and behavioral inhibition. We will also collaborate with NCANDA: SRI in a laboratory sleep study to examine the effects of alcohol on adolescent sleep architecture. Studied in the context of risks and baseline brain characteristics, we will determine both the effects of alcohol exposure on the developmental trajectory of the adolescent human brain, and identify preexisting psychobiological vulnerabilities that may put an adolescent at elevated risk for an alcohol use disorder.

描述（由申请人提供）：为了回应 RFA-AA-12-006，本申请提议国家青少年酒精和神经发育联盟（NCANDA：匹兹堡）的匹兹堡研究部分确定饮酒对青少年大脑发育的影响。在 12 岁至 21 岁之间招募的 170 名匹兹堡受试者（N = 680，来自所有地点）的高风险增强社区样本将完成基线评估，并以加速纵向设计进行三次年度随访评估。每次就诊时，都会测量多模态磁共振成像 (MRI) 方案、综合神经心理学电池、酒精和其他物质使用及相关问题的评估、心理健康症状和物质使用障碍风险因素。脑成像包括最先进的高分辨率结构 MRI (sMRI)、扩散张量成像 (DTI) 和静息态 MRI (rsMRI)。对酒精后果的检查将重点关注青春期期间活跃发育的大脑区域的结构和功能成熟度，这些区域参与心理调节，对奖励做出反应，并且被认为容易受到有毒酒精的影响。此外，NCANDA：匹兹堡将合作开展两项补充研究。我们将与 NCANDA：杜克大学合作进行一项研究，利用功能性 MRI 来检查奖赏调节反眼跳任务期间的大脑激活，以研究酒精对奖赏反应和行为抑制的影响。我们还将与 NCANDA: SRI 合作进行实验室睡眠研究，以检查酒精对青少年睡眠结构的影响。在风险和基线大脑特征的背景下进行研究，我们将确定酒精暴露对青少年人类大脑发育轨迹的影响，并确定先前存在的心理生物学脆弱性，这些脆弱性可能使青少年面临酒精使用障碍的高风险。