NCANDA Research Project Site: University of Pittsburgh (NCANDA-PITT)

项目总结 已知在青春期开始过量饮酒会干扰典型的神经发育 模式，增加患酒精使用障碍(AUD)的风险，并加速衰老过程 成人期。为响应RFA-AA-21-007，本申请提出了国家 酒精与青春期-成年期神经发育联合会(NCANDA-A)将在下一次会议上跟进 5年对三个年龄段(12-14岁，15-15岁)招募的男性和女性参与者进行多样化的社区样本调查 17，18-21岁)，当时大多数人不喝酒或不喝酒，并在过去8年中对5个地点进行了跟踪 (n=831，保留率93%)。监测涉及每年获得的多模式神经成像(MRI、DTI、 静息状态fMRI、任务fMRI)、认知、临床、行为和生物数据，亲自或 通过电脑和我们的移动应用程序远程操作。这些措施现在将得到新的先进技术的补充 神经成像、睡眠和体力活动跟踪。这一队列顺序设计独特地定位了 NCANDA-A用于量化特定青少年和早期成人的短暂或持久的酒精相关障碍 神经系统生长轨迹和功能伴随。 NCANDA-A提出了四个联合体范围的具体目标和两个专业项目目标。在目标1中，NCANDA-A 将调查青春期和成年初期过度饮酒对 认知表现、大脑结构和功能的后续发展轨迹，以及 精神变态学。目标2的分析将确定神经发育模式，描述 酒精对大脑结构和功能的影响在酗酒后的戒酒过程中会消失或持续。目标3 将部署数据驱动的分析来确定青少年的生物、环境和行为因素(例如， 开始饮酒的年龄)，这预示着在成年早期过度饮酒。在目标4中，NCANDA-A将 量化COVID大流行对生活压力以及社会、情感和经济福祉的影响，并 它们与酒精使用模式的关系。在目标5中，SRI和匹兹堡站点将确定 酒精使用、睡眠和心脏功能的模式。在目标6中，加州大学圣地亚哥分校、杜克大学和OHSU网站将确定 短期(即4周)停止饮酒在多大程度上导致精神疾病的显著改善 认知、情感、睡眠和静息心率，以及逆转不利的结构和功能脑影响 经常酗酒。对于每个目标，发育中的性别差异，酒精使用模式和历史， 酒精使用对大脑的影响，以及性别分化的心理社会因素将被测试。 随着在这次更新中收集到成年早期的纵向数据，NCANDA-A将提供新的 向公众提供有关青少年饮酒对成年人机能的持久和短暂影响的信息 发现链接这些动态过程的要素和机制，并确定可更改的风险因素。

PROJECT SUMMARY Initiating excessive alcohol drinking during adolescence is known to disturb typical neurodevelopmental patterns, increase the risk of developing alcohol use disorder (AUD), and accelerate involutional processes in adulthood. In response to RFA-AA-21-007, this application proposes a Research Project Site of the National Consortium on Alcohol and Neurodevelopment in Adolescence - Adulthood (NCANDA-A) to follow for the next 5 years a diverse community sample of male and female participants recruited in three age bands (12-14, 15- 17, 18-21 years old) when most were no-to-low drinkers and tracked over the last 8 years across 5 sites (N=831; 93% retention rate). Monitoring has involved annually acquired multimodal neuroimaging (MRI, DTI, resting state fMRI, task fMRI), cognitive, clinical, behavioral, and biological data, collected in person or remotely by computer and our mobile app. These measures will now be complemented with new advanced neuroimaging and sleep and physical activity tracking. This cohort sequential design uniquely positions NCANDA-A to quantify transient or enduring alcohol-related disturbances in specific adolescent and early adult neural system growth trajectories and functional concomitants. NCANDA-A proposes four consortium-wide specific aims and two specialty project aims. In Aim 1, NCANDA-A will investigate the impact of excessive alcohol drinking during adolescence and emerging adulthood on subsequent developmental trajectories of cognitive performance, brain structure and function, and psychopathology. Aim 2 analyses will identify neurodevelopment patterns describing the extent to which alcohol’s effects on brain structure and function resolve or persist during desistance after binge drinking. Aim 3 will deploy data-driven analysis to identify adolescent biological, environmental, and behavioral factors (e.g., age of drinking onset) that forecast excessive drinking during early adulthood. In Aim 4, NCANDA-A will quantify the impact of the COVID pandemic on life stress and social, emotional, and economic wellbeing and their relations with alcohol use patterns. In Aim 5, the SRI and Pittsburgh sites will identify interactions among patterns of alcohol use, sleep, and cardiac function. In Aim 6, the UCSD, Duke and OHSU sites will determine the extent to which short-term (i.e., 4 weeks) alcohol use discontinuation results in acute improvement in cognition, affect, sleep and resting heart rate, and reversal of the adverse structural and functional brain effects of frequent binge alcohol use. For each aim, sex differences in development, alcohol use patterns and history, impact of alcohol use on the brain, and sex-differentiating psychosocial factors will be tested. With the longitudinal data collected into early adulthood during this renewal, NCANDA-A will provide novel information to the public on the enduring and transient effects of adolescent drinking on adult functioning by discovering elements and mechanisms linking these dynamic processes and identifying modifiable risk factors.