NCANDA Research Project Site: PITT

NCANDA 研究项目地点：PITT

• 批准号: 10187458
• 负责人: DUNCAN B. CLARK
• 金额: $ 44.49万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-05 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10187458
• 关键词: Abstinence; Address; Adolescence; Adolescent; Adolescent Development; Adult; Adverse effects; Affective; Age; Alcohol consumption; Alcohols; Area; Behavior assessment; Behavioral; Biological; Brain; Chronic; Clinical assessments; Cognitive; Collection; Corpus striatum structure; Data; Development; Dose; Ecological momentary assessment; Event; Foundations; Functional Magnetic Resonance Imaging; Health; Heavy Drinking; Human; Individual; Intervention; Life; Magnetic Resonance Imaging; Measures; Mediating; Mental disorders; Neurobiology; Outcome; Parietal; Participant; Pattern; Phase; Prevention; Psychosocial Factor; Recovery; Regulation; Reporting; Research Project Grants; Rewards; Risk; Sampling; Sex Differences; Sex Differentiation; Site; Sleep; Statistical Models; Stress; Structure; Subgroup; Symptoms; System; Teenagers; Variant; Visit; Work; alcohol consequences; alcohol effect; alcohol expectancy; alcohol exposure; alcohol measurement; alcohol risk; alcohol use disorder; binge drinking; cognitive control; cognitive development; cognitive testing; cohort; depressive symptoms; drinking; drinking onset; emerging adult; experience; externalizing behavior; information processing; longitudinal analysis; longitudinal design; multimodality; neural circuit; neurodevelopment; neuroimaging; neurotoxic; psychobiologic; psychologic; relating to nervous system; resilience; response; sex; substance use; twelfth grade; underage drinking; young adult

PROJECT SUMMARY During young adulthood, drinking dramatically increases, with binge-level drinking peaking at age 22 and nearly half of individuals reporting binge-level alcohol use. Frequent binge alcohol use during the protracted neuromaturation spanning into the mid-20s may result in greater brain and cognitive effects than similar alcohol use in later adulthood. In response to RFA-AA-17-003, this application proposes a Research Project Site of the National Consortium on Alcohol and Neurodevelopment in Adolescence second phase (NCANDA-2) to determine the predictors and effects of heavy alcohol use in adolescence and young adulthood. To achieve this, the Pittsburgh site of NCANDA-2 will continue to follow a cohort of 125 Pittsburgh-area (n=831 across all 5 sites) participants (ages 12-21 at baseline first visit) to acquire the necessary data to advance our understanding of adolescent development and the effects of alcohol use during adolescence on the adult brain. NCANDA-2 will use multimodal neuroimaging, cognitive testing, behavioral assessment, biospecimen collection, and ecological momentary assessment. The examination of alcohol consequences will focus on structural and functional maturation of brain areas that actively develop during adolescence, are involved in psychological regulation, respond to rewards, and appear vulnerable to neurotoxic effects of alcohol. In addition, the Pittsburgh site will collaborate with the SRI sites to study sleep-related predictors and effects of alcohol use in a subgroup of adolescents. Pittsburgh will also collaborate with the Duke site to collect the Rewarded Antisaccade fMRI task to evaluate changes in the reward and cognitive control systems in relationship to alcohol use. Sex differences in development, alcohol use patterns, impact of alcohol use on the brain, and sex-differentiating psychosocial factors (e.g., depression symptoms) will be considered in analyses. With the additional longitudinal data provided by this renewal, we will determine the effects of alcohol exposure on the developmental trajectory of the adolescent human brain, and identify preexisting psychobiological vulnerabilities that may put an adolescent or young adult at elevated risk for an alcohol use disorder.

项目摘要 在年轻的成年期，饮酒量急剧增加，22岁时达到顶峰， 近一半的人报告酗酒。长期饮酒期间频繁酗酒 神经成熟跨越到20多岁中期可能会导致更大的大脑和认知效果比类似的 成年后的酒精使用作为对RFA-AA-17-003的回应，本申请提出了一项研究项目 国家酒精和青少年神经发育联盟第二阶段（NCANDA-2） 以确定青少年和年轻成年人大量饮酒的预测因素和影响。实现 因此，NCANDA-2的匹兹堡研究中心将继续随访125名匹兹堡地区的队列（所有研究中n=831）。 5个研究中心）参与者（基线首次访视时年龄为12-21岁），以获取必要的数据， 了解青少年的发展和青少年时期饮酒对成年人大脑的影响。 NCANDA-2将使用多模式神经成像、认知测试、行为评估、生物样本 收集和生态瞬时评估。对酒精后果的审查将集中在 在青春期活跃发育的大脑区域的结构和功能成熟， 心理调节，对奖励做出反应，似乎容易受到酒精的神经毒性影响。在 此外，匹兹堡研究中心将与SRI研究中心合作，研究与睡眠相关的预测因素和 青少年中的酒精使用。匹兹堡还将与杜克网站合作，收集 奖励的抗accade fMRI任务，以评估奖励和认知控制系统的变化， 与酒精使用的关系。发展中的性别差异，酒精使用模式，酒精使用对 大脑，以及性别区分的心理社会因素（例如，抑郁症状）将在分析中考虑。 通过这次更新提供的额外纵向数据，我们将确定酒精暴露的影响 青少年大脑的发育轨迹，并确定先前存在的心理生物学 脆弱性可能会使青少年或年轻人处于酒精使用障碍的高风险中。