ABCD-USA Consortium:Research Project

ABCD-美国联盟：研究项目

• 批准号: 9281715
• 负责人: DUNCAN B. CLARK
• 金额: $ 76.51万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-30 至 2020-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9281715
• 关键词: 10 year old; Address; Adolescence; Adolescent; Adolescent Development; Adolescent marijuana use; Adult; Age; Alcohol or Other Drugs use; Alcohols; Area; Behavioral; Biological; Biological Assay; Brain; Brain imaging; Characteristics; Child; Child Development; Childhood; Clinical assessments; Cognition; Cognitive; Communities; County; Data; Data Analyses; Department chair; Development; Dimensions; Elements; Eligibility Determination; Ensure; Environment; Family; Foundations; Genetic; Human; Image; Individual; Informatics; Institutes; International; Link; Logistics; Longitudinal Studies; Machine Learning; Marijuana; Measures; Mental Health; Methodology; Modality; Modeling; Monitor; Neurobiology; Neurocognitive; Neuropsychological Tests; Neurosciences; Outcome; Participant; Pattern; Phenotype; Process; Psychiatry; Psychopathology; Recruitment Activity; Reporting; Research; Research Infrastructure; Research Project Grants; Rest; Risk; Sampling; Services; Short-Term Memory; Site; Social Functioning; Standardization; Statistical Methods; Substance Use Disorder; Symptoms; System; Technology; Uncertainty; Universities; Youth; adolescent substance use; behavioral health; cognitive development; cognitive function; cognitive task; cognitive testing; disorder risk; early onset; emerging adult; experience; high risk; improved; innovation; marijuana use; misuse of prescription only drugs; multimodality; neural circuit; neuroimaging; nonhuman primate; predictive modeling; programs; prospective; psychologic; psychological outcomes; public health relevance; response; social; time use; translational research program; trend

 DESCRIPTION (provided by applicant): Adolescence is a critical neurodevelopmental period that is associated with dramatic increases in rates of substance use. Identifying predictors of substance use and its effects on child and adolescent development is critically important, as substance-related decrements incurred during ongoing maturation could have long- lasting effects on brain functioning and behavioral, health, and psychological outcomes. In response to RFA- DA-15-015, this application proposes the University of Pittsburgh Research Project Site component [12/13] of the Adolescent Brain Cognitive Development (ABCD)-USA consortium to prospectively determine the neurodevelopmental and behavioral effects of substance on children and adolescents. In Pittsburgh, a representative community sample of 550 9-10 year old substance-naïve children will be recruited (total ABCD- USA n=11,111 from 11 total sites) and will undergo a baseline assessment and two to three follow-ups over a five year period. At each assessment period, participants will undergo state-of-the-art brain imaging, comprehensive neuropsychological testing, and extensive assessment of substance use patterns and mental health functioning. The brain, behavioral, psychological, social, genetic, and environmental data collected during the course of this project will elucidate: 1) the effects o substance use patterns on the adolescent brain; 2) the effects of substance use on behavioral and health outcomes; 3) the bidirectional relationship between psychopathology and substance use patterns; 4) the effects of individual genetic, behavioral, neurobiological, and environmental differences on risk profiles and substance use outcomes; and 5) the "gateway interactions" between use of different substances. Elements Unique to This Site: In addition, ABCD-USA Pittsburgh will provide a unique focus determining how the cognitive dimensions of working memory and inhibitory control and the maturation of corticostriatal systems can inform our understanding of the risks for and effects of early adolescent marijuana use. Working memory and inhibitory control improve during adolescence in parallel with maturation of underlying corticostriatal neurocircuitry. An understanding of these areas of adolescent brain and cognitive development provide critical information in models determining vulnerabilities for and consequences of marijuana and other substance use. In Y03, Pittsburgh will focus on analyses examining working memory and inhibitory control phenotypes and neurodevelopmental characteristics prior to substance use. In Y04-Y05, these neurocognitive characteristics will be examined as risks for early adolescent marijuana use trajectories and, in Y10, accelerated adolescent marijuana use trajectories. Machine Learning will be applied to integrating cognitive and neuroimaging features to characterize a model of risks for early adolescent marijuana use.

 描述（由申请人提供）：青春期是一个关键的神经发育时期，与物质使用率的急剧增加有关。确定物质使用及其对儿童和青少年发育影响的预测因素至关重要，因为在持续成熟期间发生的物质相关的减少可能对大脑功能以及行为，健康和心理结果产生长期影响。作为对RFA- DA-15-015的回应，本申请提出了青少年大脑认知发育（ABCD）-美国联盟的匹兹堡大学研究项目现场组件[12/13]，以前瞻性地确定物质对儿童和青少年的神经发育和行为影响。在匹兹堡，将招募550名9-10岁药物初治儿童的代表性社区样本（ABCD- USA共计11个研究中心，n= 11，111），并将在5年内进行基线评估和2 - 3次随访。在每个评估期间，参与者将接受最先进的大脑成像，全面的神经心理学测试，以及对物质使用模式和心理健康功能的广泛评估。本研究收集的大脑、行为、心理、社会、遗传和环境数据将阐明：1）物质使用模式对青少年大脑的影响; 2）物质使用对行为和健康结果的影响; 3）精神病理学和物质使用模式之间的双向关系; 4）个体遗传、行为、神经生物学和环境差异对风险状况和物质使用结果的影响; 5）使用不同物质之间的“网关相互作用”。本网站独有的元素：此外，ABCD-USA匹兹堡将提供一个独特的重点，确定工作记忆和抑制控制的认知维度以及皮质纹状体系统的成熟如何能够告知我们对青少年早期使用大麻的风险和影响的理解。工作记忆和抑制性控制在青春期的改善与潜在的皮质纹状体神经回路的成熟平行。对青少年大脑和认知发展这些领域的了解，为确定大麻和其他物质使用的脆弱性和后果的模型提供了关键信息。在2003年，匹兹堡将重点分析检查工作记忆和抑制控制表型和神经发育特征之前，物质的使用。在Y 04-Y 05，这些神经认知特征将被检查为早期青少年大麻使用轨迹的风险，并在Y10，加速青少年大麻使用轨迹。机器学习将被应用于整合认知和神经成像特征，以表征早期青少年大麻使用的风险模型。