PHARMACOLOGY OF ANTIRHEUMATIC AGENTS

抗风湿药的药理学

• 批准号: 6276996
• 负责人: BRUCE Neil CRONSTEIN
• 金额: $ 2.03万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6276996
• 关键词: adenosine; antiinflammatory agents; biological signal transduction; clinical research; clinical trials; drug screening /evaluation; enzyme linked immunosorbent assay; human subject; human therapy evaluation; methotrexate; northern blottings; nucleic acid chemical synthesis; polymerase chain reaction; rheumatoid arthritis; skeletal disorder chemotherapy; skeletal pharmacology; sulfanilamides

This study demonstrates that in in vivo models and patients with rheumatoid arthritis the effects of antiinflammatory drugs, specifically methotrexate and sulfasalzine, are due to their capacity to increase extracellular adenosine. The investigators have concluded that signal transduction of adenosine proceeds by a novel pathway. The lab was used for ELISA, oligonucleotide synthesis, PCR and recombinant DNA techniques.

这项研究表明，在体内模型和患者中， 类风湿性关节炎的治疗方法有哪些？ 甲氨蝶呤和柳氮磺胺吡啶，是由于他们的能力，以增加 细胞外腺苷调查人员得出结论， 腺苷的转导通过新的途径进行。实验室被用来 用于ELISA、寡核苷酸合成、PCR和重组DNA 技术.