AGING ON BONE MINERAL CONTENT OF RHESUS: OSTEOPOROSIS

摘要目的：探讨生长发育和衰老对骨骼的影响。 恒河猴的新陈代谢。结果东半球的猴子经常 作为骨骼发育和衰老的模型，然而，年龄 峰值骨量和增龄的影响还不是很清楚。这个 本研究的目的是使用DXA和骨代谢测量 为了更清楚地描述恒河猴骨骼发育和衰老的特征 猴子让他们更好地理解骨质疏松症模型和 老龄化研究。雌性恒河猴60只，雄性恒河猴56只(4-34岁) 对上述端点进行了研究。峰值骨量通过以下方式达到 大约10年。两组均为适龄患者。在男性中，有一种 随着年龄的增长显著下降(p&lt；0.001)(基于回归分析) 腰椎侧位骨矿含量(BMC)和骨密度(BMD) 脊柱、股骨和桡骨远端。此外，骨骼的周转率下降。 随着年龄的增长。根据内分泌数据和月经周期，女性 分为3组，成年组(G，n=12)、成年组(A，n=31)和老年组(O， N=17)。O类动物的总体体重低于A类动物(P&lt；0.05) BMC、前后椎BMD、桡骨近端BMC和BMD。 骨钙素、25-羟基维生素D和钙的水平也 与A组相比，O组显著降低(p&lt；0.05)。此外, 对腰椎X线片进行调整，以调整治疗效果。 骨性关节炎患者骨密度和骨矿含量的测定。在男性和女性中， 脊椎病的发病率显著增加(p&lt；0.001)。 随年龄增长的骨性关节炎。我们计划继续使用的未来方向 DXA、X线片和骨代谢标志物以更好地表征 恒河猴的骨骼老化过程使它们变得更好 了解骨质疏松症研究的模型。关键词骨质疏松症 骨密度、衰老、骨代谢、DXA

OBJECTIVE: To assess the effect of growth and aging upon bone metabolism in rhesus monkeys. RESULTS Old world monkeys are often used as models for skeletal development and aging however, the age of peak bone mass and the effect of advancing age is not well known. The aim of this study was to use DXA and measurements of bone metabolism to more clearly characterize skeletal development and aging in rhesus monkeys making them better understood models for osteoporosis and aging research. Sixty female and 56 male rhesus monkeys (4-34 yr.-) were studied for the above endpoints. Peak bone mass was achieved by approximately 10 yrs. of age in both groups. In males, there was a significant decline (p<0.001) with age (based on regression analysis) in bone mineral content (BMC) and density (BMD) of the lateral lumbar spine, femur and distal radius. In addition, bone turnover decreased with age. Using endocrine data and menstrual cyclicity, females were divided into 3 groups, growing (G, n=12), adult (A, n=31) and old (O, n=17). O animals were lower (p<0.05) than A animals in total body BMC, anterior-posterior spine BMD and proximal radius BMC and BMD. Osteocalcin, 25-hydroxyvitamin D and calcium levels were also significantly (p<0.05) lower in O compared to A animals. In addition, lumbar spine radiographs were taken to adjust for the effect of osteoarthritis on measurements of BMC and BMD. In males and females, there was a significant (p<0.001) increase in the incidence of spinal osteoarthritis with age. FUTURE DIRECTIONS We plan to continue using DXA, radiographs and markers of bone metabolism to better characterize the skeletal aging process in rhesus monkeys making them better understood models for osteoporosis research. KEY WORDS Osteoporosis, bone density, aging, bone metabolism, DXA