NOISE AND THE NEURAL REPRESENTATION OF PURE TONES IN THE AUDITORY SYSTEM
噪声与听觉系统中纯音的神经表征
基本信息
- 批准号:6104389
- 负责人:
- 金额:$ 10.15万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1998
- 资助国家:美国
- 起止时间:1998-09-01 至 1999-08-31
- 项目状态:已结题
- 来源:
- 关键词:audiometry auditory cortex auditory discrimination auditory nuclei behavioral /social science research tag behavioral habituation /sensitization binaural hearing brain mapping cats electrophysiology environmental adaptation inferior colliculus microelectrodes neural information processing noise single cell analysis stereotaxic techniques
项目摘要
This project will use extracellular electrophysiological recording to
study the effects of background noise on the neural representation of pure
tone stimuli. Neural responses will be measured in terms of average
discharge rates for single units. Dynamic range properties of single-unit
responses will be derived from measures of rate-level functions that are
obtained in quiet and in the presence of continuous background noise.
Dynamic range measures will be sampled in the dorsal cochlear nucleus,
inferior colliculus and primary auditory cortex of behaving cats.
Inhibitory mechanisms that shape the neural representation of tones in
noise at each of these three levels of auditory processing will be
described by frequency response maps, responses to bandpass noise, and
responses to broad band noise with notched spectra. This research is based
on independent observations that inhibitory influences increasingly reduce
auditory responses to continuous noise at higher levels of the auditory
system. A reduction in noise-driven activity potentially enhances the rate
representation of signals that occur in the presence of background noise
by decreasing the negative effects of noise adaptation The primary
objectives of this proposal are to demonstrate changes in noise adaptation
across three levels of auditory processing, to reveal neural inhibitory
mechanisms that contribute to changes in noise-driven activity, and to
measure the functional consequences of these changes in terms of the
quality of neural representations for signals in noise. Although some of
these objectives have been addressed in the nervous system of anesthetized
and decerebrate cats, a comprehensive analysis of the neural encoding of
pure tones in noisy environments has not been performed in behaving cats.
Data obtained in behaving cats are critical to our understanding of noise
adaptation because anesthesia substantially alters activity of descending
efferent projections to the auditory periphery and inhibitory mechanisms
at each subsequent level of auditory processing.
本项目将使用细胞外电生理记录,
研究背景噪声对纯脑的神经表征的影响
音调刺激神经反应将以平均
单个单位的排放率。单个单元的动态范围特性
响应将来自率级函数的测量,
在安静和存在连续背景噪声的情况下获得。
动态范围测量将在耳蜗背核中采样,
下丘和初级听觉皮层。
抑制机制,塑造神经表征的音调,
这三个听觉处理水平中的每一个的噪声将被
由频率响应图描述,对带通噪声的响应,以及
对具有陷波频谱的宽带噪声的响应。本研究立足
根据独立观察,抑制性影响越来越少,
听觉反应连续噪声在较高水平的听觉
系统噪音驱动活动的减少可能会提高
在存在背景噪声的情况下出现的信号表示
通过减少噪音适应的负面影响
本提案的目的是证明噪音适应的变化
在听觉处理的三个层次上,揭示神经抑制
有助于改变噪音驱动活动的机制,以及
衡量这些变化的功能后果,
噪声中信号的神经表征质量。虽然有些
这些目标已经在麻醉的神经系统中得到解决
和去大脑猫,对神经编码的全面分析,
在嘈杂环境中的纯音还没有在行为猫中进行。
从猫的行为中获得的数据对我们理解噪音至关重要
适应,因为麻醉实质上改变了下行活动,
听觉外周的传出投射及其抑制机制
在每一个后续的听觉处理水平。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('BRADFORD J MAY', 18)}}的其他基金
NOISE AND THE NEURAL REPRESENTATION OF PURE TONES IN THE AUDITORY SYSTEM
噪声与听觉系统中纯音的神经表征
- 批准号:
6201697 - 财政年份:1999
- 资助金额:
$ 10.15万 - 项目类别:
NOISE AND THE NEURAL REPRESENTATION OF PURE TONES IN THE AUDITORY SYSTEM
噪声与听觉系统中纯音的神经表征
- 批准号:
6238192 - 财政年份:1997
- 资助金额:
$ 10.15万 - 项目类别:
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