EFFECTS OF SB207266-A ON TRANSIT AND COLONIC MOTOR & SENSORY FUNCTION

SB207266-A 对转运和结肠运动的影响

• 批准号: 6278629
• 负责人: M CAMILLERI
• 金额: $ 2.03万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6278629
• 关键词: clinical research; dosage; drug screening /evaluation; gastrointestinal absorption /transport; gastrointestinal disorder chemotherapy; gastrointestinal motility /pressure; gastrointestinal sign /symptom; human subject; pharmacokinetics; serotonin inhibitor

This study assessed pharmacodynamics of a unique 5HT4 antagonist, SB207266-A, on transit, and colonic motor and sensory function in healthy humans. The investigators anticipate that the drug will dose- dependently affect overall GI transit but not alter fasting tone. A significant effect on colonic compliance, a reduction in the colinic response to meal ingestion and in the perception of colonic balloon distention.

这项研究评估了一种独特的 5HT4 拮抗剂的药效学， SB207266-A，关于运输、结肠运动和感觉功能 健康的人类。 研究人员预计该药物将剂量- 依赖地影响整体胃肠道运输，但不改变空腹语气。 一个 对结肠顺应性有显着影响，减少结肠 对膳食摄入的反应和结肠气球的感知 腹胀。