VALIDATION OF 13C-OCTANOATE BREATH TEST--GASTRIC EMPTYING

13C-辛酸呼吸试验的验证——胃排空

• 批准号: 6117448
• 负责人: M CAMILLERI
• 金额: $ 2.01万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6117448
• 关键词: autoradiography; breath tests; carbon; clinical research; diagnosis design /evaluation; diagnosis quality /standard; gastrointestinal disorder diagnosis; human subject; mathematical model; stable isotope; stomach emptying

This study is validating the use of breath test compared to scintigraphy for measurement of gastric emptying and preliminary results indicate that analytical methods published in the literature are inadequate. We are therefore applying novel mathematical models to breath test data to more accurately "predict" scintigraphic gastric emptying data. We have completed this protocol. We performed simultaneous 13C-octanoic acid breath test and scintigrahy in 23 patients with diabetes and 6 healthy volunteers. Preliminary data of this work was presented at the American Gastroenterological Association Annual Meeting in May 1998. We are now developing a new, accurate model for solid gastric empthing using a multiple linear regression analysis with the same method previously used in the 13C-spirulina breath test; a full manuscript of this work will be submitted for publication.

本研究验证了呼吸试验与胃排空造影术相比用于测量胃排空的使用，初步结果表明文献中发表的分析方法不充分。 因此，我们将新的数学模型应用于呼吸测试数据，以更准确地“预测”胃排空数据。我们已经完成了这个协议。 我们对23例糖尿病患者和6例健康志愿者同时进行了13 C-辛酸呼气试验和肺动脉造影。 这项工作的初步数据在1998年5月的美国胃肠病学协会年会上发表。 我们现在正在开发一种新的，准确的模型，固体胃排空使用多元线性回归分析与以前使用的13 C-螺旋藻呼吸试验相同的方法，这项工作的完整手稿将提交出版。