13C SPIRULINA BREATH TEST FOR MEASURING GASTRIC EMPTYING OF SOLIDS

13C 螺旋藻呼吸测试，用于测量胃固体排空

• 批准号: 6117471
• 负责人: M CAMILLERI
• 金额: $ 2.01万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6117471
• 关键词: autoradiography; breath tests; carbon; clinical research; diagnosis design /evaluation; gastrointestinal disorder diagnosis; human subject; stable isotope; stable isotope diagnosis; stomach emptying

To develop a nonradioactive breath test using the stable isotope 13C Spirulina for measuring gastric emptying of solids. To assess the correlation between t 1/2 obtained from 13C Spirulina breath test and t 1/2 of the simultaneously performed scintigraphic technique in health subjects. This study will most likely validate a new method to noninvasively measure gastric emptying using stable isotopes. It has immense potential for studies of nausea, vomiting and abdominal symptoms in pediatric and obstetric practice and in community or epidemiologic studies. We performed simultaneous 13C-spirulina breath test and scintigraphy in 30 healthy volunteers from November 11, 1997, to March 13, 1998. From these data, we developed a new accurate model for solid gastric empthing using multiple linear regression analysis and wrote an abstract which we will present at the Biennial Meeting of the American Motility Society this month in Philadelphia.

开发一种使用稳定同位素13C螺旋藻的无放射性呼吸试验，用于测量胃中固体排空。目的探讨13C螺旋藻呼吸试验结果与同期进行的螺旋藻呼吸试验结果的相关性。这项研究很可能验证一种使用稳定同位素无创测量胃排空的新方法。它在儿科和产科实践以及社区或流行病学研究中对恶心、呕吐和腹部症状的研究具有巨大的潜力。从1997年11月11日至1998年3月13日，我们对30名健康志愿者同时进行了13c螺旋藻呼吸测试和闪烁成像。根据这些数据，我们利用多元线性回归分析开发了一种新的精确的固体胃排空模型，并撰写了一份摘要，我们将于本月在费城举行的美国动力学会两年一次的会议上发表。