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W BAND SPECTRA OF MODEL NEUROMELANINS

W BAND SPECTRA OF MODEL NEUROMELANINS
模型神经黑色素的 W 波段光谱
批准号：
6120600
负责人：
MARK R NILGES
金额：
$0.05万
依托单位：
UNIVERSITY OF ILLINOIS AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-04-15 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6120600
关键词：
biological products biomaterials biomedical resource nervous system proteins

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英文摘要
Various model melanins, based upon precursors such as dopamine, cysteine, glutathione and mixtures thereof, have been characterized with W-band EPR spectroscopy. Spectra of different model melanins are markedly different. Particularly, the degree of solubilization of polymer correlates very well with the ratio of semiquinone and/or semiquinone imine signal to intrinsic free radical signal. Results indicate that model dopamine melanin is not a good model for neuromelanin, and that neuromelanin incorporates cysteine and/or glutathione. This is a continuing multi-year project.
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