W BAND SPECTRA OF MODEL NEUROMELANINS

模型神经黑色素的 W 波段光谱

• 批准号: 6120600
• 负责人: MARK R NILGES
• 金额: $ 0.05万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-04-15 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6120600
• 关键词: biological products; biomaterials; biomedical resource; nervous system; proteins

Various model melanins, based upon precursors such as dopamine, cysteine, glutathione and mixtures thereof, have been characterized with W-band EPR spectroscopy. Spectra of different model melanins are markedly different. Particularly, the degree of solubilization of polymer correlates very well with the ratio of semiquinone and/or semiquinone imine signal to intrinsic free radical signal. Results indicate that model dopamine melanin is not a good model for neuromelanin, and that neuromelanin incorporates cysteine and/or glutathione. This is a continuing multi-year project.

各种模型黑色素，基于前体，如多巴胺， 半胱氨酸、谷胱甘肽和它们的混合物， 用W波段EPR光谱 不同模型黑色素的光谱是 明显不同 特别地，可以提高聚合物的增溶程度。 聚合物与半醌和/或 半醌亚胺信号与固有自由基信号的比值。 结果 表明模型多巴胺黑色素不是用于 神经黑色素，并且神经黑色素掺入半胱氨酸和/或 谷胱甘肽 这是一个持续多年的项目。