CORE--ANALYTICAL CHEMISTRY AND BIOMARKERS

分析化学和生物标志物核心提供最先进的 以质谱仪、层析、有机为特色的化学服务 合成和分析生物化学。进行了质谱分析 三种乐器：芬兰垫子TSQ 7000三重四极杆质量 液色谱(LC)和气相色谱(GC)光谱仪 界面；带LC的Sciex API III三重四极质谱计 接口和Hewlett-Packard G2025A激光解吸-飞行时间 质谱仪。层析服务包括协助 高效液相色谱仪和气相色谱仪的应用及故障排除与维护 乐器。有机合成包括制备和合成 作为标准的癌症中心成员所需化合物的表征 以及中心调查人员使用的化合物的纯度评估。 分析生物化学服务包括广泛的分析 人体尿液和组织中代谢物和加合物的特征。 分析化学和生物标志物核心因此成为 提供全方位的化学和生化服务支持的专业知识 中心研究人员的同行评议研究。

The Analytical Chemistry and Biomarkers Core provides state of the art chemistry services featuring mass spectrometry, chromatography, organic synthesis, and analytical biochemistry. Mass spectroscopy is carried out with three instruments: a Finnigan MAT TSQ 7000 Triple Quadrupole Mass Spectrometer with Liquid Chromatography (LC) and Gas Chromatography (GC) interfaces; a Sciex API III Triple Quadrupole Mass Spectrometer with LC interface, and a Hewlett-Packard G2025A Laser Desorption-Time of Flight Mass Spectrometer. Chromatography services include assistance with the application of HPLC and GC methods and trouble-shooting and maintenance of instruments. Organic synthesis includes the preparation and characterization of compounds needed by Cancer Center members as standards as well as purity assessments on compounds used by Center investigators. Analytical biochemistry services include a wide range of assays for characterization of metabolites and adducts in human urine and tissues. The Analytical Chemistry and Biomarkers Core thus services as a center of expertise for a full range of chemical and biochemical services in support of the peer-reviewed research of Center investigators.