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PET STUDY OF CNS BENZODIAZEPINE RECEPTORS IN ADOLESCENT ONSET ALCOHOLISM

PET STUDY OF CNS BENZODIAZEPINE RECEPTORS IN ADOLESCENT ONSET ALCOHOLISM
青少年酒精中毒中枢神经系统苯二氮卓受体的 PET 研究
批准号：
6219262
负责人：
DUNCAN B. CLARK
金额：
$0.3万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6219262
关键词：
adolescence (12-20) alcoholic beverage consumption alcoholism /alcohol abuse benzodiazepine receptor central nervous system disorders clinical research human subject neurochemistry positron emission tomography receptor expression receptor sensitivity toxicant interaction toxicology

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英文摘要
This study proposes to obtain pilot data on the effects of chronic and alcohol consumption on benzodiazepine receptor (BZR) distribution and density in adolescent onset alcohol dependence using [11C] flumazenil binding visualized by PET. Alterations in the gamma-aminobutyric acid (GABA) neurotransmitter system induced by chronic alcohol consumption represent the mostly likely neurochemical substrate of alcohol dependence. Subjects with adolescent-onset alcohol use disorders, compared with controls, will show reduced binding of [11C]-flumazenil in the cingulate cortex.
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