Downsizing A Human Protein To Modulate Inflammatory Diseases

缩小人类蛋白质的大小以调节炎症疾病

• 批准号: nhmrc : 1084018
• 负责人: Prof David Fairlie
• 金额: $ 34.46万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/downsizing-human-protein-inflammatory-diseases/518973
• 关键词: Downsizing; Human; Protein; Modulate; Inflammatory

We have discovered how to downsize a human protein to very small molecules with the same activities and potencies. Small changes enable the compounds to powerfully block the actions of the protein. These small molecules are very stable in blood, whereas the protein deactivates in minutes. This project will develop the small molecules into experimental drugs and test them in human cells and proteins, and in rats to evaluate their potential for treating human inflammatory diseases.

我们已经发现了如何将人类蛋白质缩小到具有相同活性和效力的非常小的分子。微小的变化使化合物能够有力地阻止蛋白质的作用。这些小分子在血液中非常稳定，而蛋白质在几分钟内就会失活。该项目将把这些小分子开发成实验药物，并在人体细胞和蛋白质以及大鼠中进行测试，以评估它们治疗人类炎症性疾病的潜力。