Engineering peptides into superglues selective for target proteins

将肽工程化为对目标蛋白具有选择性的强力胶

• 批准号: DP160104442
• 负责人: Prof David Fairlie
• 金额: $ 37.48万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP160104442
• 关键词: Engineering; peptides; into; superglues; selective

This project aims to discover how to create long-acting peptides for future research tools, drugs, biosensors and diagnostics. Peptides are currently viewed by the general community as injectable performance-enhancing drugs which are difficult to detect because they don't last very long. However, peptides have many potential benefits that are difficult to obtain because of their short durations of action. This project aims to develop ways of engineering peptide shapes into nanoscale superglues that stick more tightly but selectively to their target proteins, thereby extending their durations of action. Technology for engineering superglues would produce proof of concept and prototypes for future research tools, drugs, diagnostics and biosensors.

该项目旨在探索如何为未来的研究工具、药物、生物传感器和诊断创造长效肽。目前，肽被普遍认为是可注射的性能增强药物，但由于它们的持续时间不长，因此很难检测到。然而，肽有许多潜在的好处，但由于其作用持续时间短而难以获得。该项目旨在开发将肽形状工程化为纳米级强力胶的方法，这些强力胶可以更紧密地但选择性地粘附到目标蛋白质上，从而延长其作用持续时间。强力胶工程技术将为未来的研究工具、药物、诊断和生物传感器提供概念验证和原型。