Small Molecule Modulators of Complement in Metabolism and Obesity
Small Molecule Modulators of Complement in Metabolism and Obesity
批准号:
nhmrc : 1028423
负责人:
Prof David Fairlie
金额:
$45.53万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2012
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2012-01-01 至 2015-12-31
中文摘要
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英文摘要
We have discovered that certain inflammatory proteins in the blood that are produced in the immune response to infection are involved in regulating the storage and burn off of fat in adipose tissue in the abdomen. These proteins bind to the surfaces of both fat and immune cells. We will study the effects of new drugs that compete with these blood proteins for the surfaces of these cells, since our experiments indicate that such drugs can potentially prevent and reverse fat deposition in rats fed a high-fat, high-carbohydrate, diet.
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Super-resolution platform to accelerate biological and molecular research
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批准号:LE240100134
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项目类别:Linkage Infrastructure, Equipment and Facilities
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资助金额:$53.09万
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财政年份:2024
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负责人:Prof David Fairlie
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依托单位:
Compressing small peptides for cell absorption
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批准号:DP180103244
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项目类别:Discovery Projects
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资助金额:$40.43万
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财政年份:2018
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负责人:Prof David Fairlie
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依托单位:
Combating infectious diseases by harnessing macrophage functions
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批准号:nhmrc : GNT1125316
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项目类别:Project Grants
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资助金额:$68.82万
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财政年份:2017
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负责人:Prof David Fairlie
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依托单位:
Modulating Protein-Protein Interactions In Disease
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批准号:nhmrc : GNT1117017
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项目类别:Research Fellowships
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资助金额:$86.39万
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财政年份:2017
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负责人:Prof David Fairlie
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依托单位:
Combating infectious diseases by harnessing macrophage functions
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批准号:nhmrc : 1125316
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项目类别:Project Grants
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资助金额:$46.96万
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财政年份:2017
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负责人:Prof David Fairlie
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依托单位:
Modulating Protein-Protein Interactions In Disease
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批准号:nhmrc : 1117017
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项目类别:Research Fellowships
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资助金额:$59.07万
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财政年份:2017
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负责人:Prof David Fairlie
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依托单位:
Engineering peptides into superglues selective for target proteins
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批准号:DP160104442
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项目类别:Discovery Projects
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资助金额:$37.48万
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财政年份:2016
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负责人:Prof David Fairlie
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依托单位:
Engineering Cyclic Peptides For Oral Bioavailability
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批准号:DP150104609
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项目类别:Discovery Projects
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资助金额:$34.7万
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财政年份:2015
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负责人:Prof David Fairlie
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依托单位:
Development of antimalarial histone deacetylase inhibitors
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批准号:nhmrc : GNT1093378
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项目类别:Development Grants
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资助金额:$55.68万
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财政年份:2015
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负责人:Prof David Fairlie
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依托单位:
Development of antimalarial histone deacetylase inhibitors
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批准号:nhmrc : 1093378
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项目类别:Development Grants
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资助金额:$38.25万
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财政年份:2015
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负责人:Prof David Fairlie
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依托单位:
Downsizing A Human Protein To Modulate Inflammatory Diseases
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批准号:nhmrc : 1084018
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项目类别:Project Grants
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资助金额:$34.46万
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财政年份:2015
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负责人:Prof David Fairlie
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依托单位:
Anti-Parasitic Drug Discovery in Epigenetics
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批准号:nhmrc : 1074016
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项目类别:Targeted Calls
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资助金额:$18.15万
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财政年份:2014
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负责人:Prof David Fairlie
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依托单位:
Downsizing proteins to equipotent small molecules that activate cells
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批准号:DP130100629
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项目类别:Discovery Projects
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资助金额:$34.11万
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财政年份:2013
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负责人:Prof David Fairlie
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依托单位:
Capturing New Drugs That Selectively Modulate PAR2 Signaling Pathways
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批准号:nhmrc : 1047759
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项目类别:Project Grants
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资助金额:$31.28万
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财政年份:2013
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负责人:Prof David Fairlie
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依托单位:
Flaviviral proteases as viable targets for antiinfective drugs
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批准号:nhmrc : 1025883
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项目类别:Project Grants
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资助金额:$41.39万
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财政年份:2012
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负责人:Prof David Fairlie
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依托单位:
Research Fellowship
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批准号:nhmrc : 1027369
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项目类别:Research Fellowships
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资助金额:$55.8万
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财政年份:2012
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负责人:Prof David Fairlie
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依托单位:
Profiling global inflammatory signatures for GPCRs in human macrophages
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批准号:nhmrc : 1030169
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项目类别:Project Grants
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资助金额:$45.86万
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财政年份:2012
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负责人:Prof David Fairlie
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依托单位:
Protein And Peptide Alpha Turns
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批准号:DP1096290
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项目类别:Discovery Projects
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资助金额:$25.08万
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财政年份:2010
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负责人:Prof David Fairlie
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依托单位:
Protease Activated Receptor 2 Antagonist In Inflammatory Disease
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批准号:nhmrc : 1000745
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项目类别:NHMRC Development Grants
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资助金额:$41.43万
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财政年份:2010
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负责人:Prof David Fairlie
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依托单位:
Common hot spots in protein-activated GPCRs enable discovery of new ligands for mapping of G-protein signalling pathways
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项目类别:Discovery Projects
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资助金额:$62.7万
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财政年份:2010
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负责人:Prof David Fairlie
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依托单位:
国内基金
海外基金
D-A类共轭聚合物晶界内部tie molecule构象调控
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批准号:51573185
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项目类别:面上项目
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资助金额:70.0万元
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批准年份:2015
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负责人:韩艳春
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依托单位:
耦合可积系统及其molecule解的研究
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批准号:11026119
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项目类别:数学天元基金项目
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资助金额:3.0万元
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批准年份:2010
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负责人:王红艳
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依托单位: