Modulating Protein-Protein Interactions In Disease

调节疾病中的蛋白质-蛋白质相互作用

• 批准号: nhmrc : GNT1117017
• 负责人: Prof David Fairlie
• 金额: $ 86.39万
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/modulating-protein-protein-interactions-disease/1347005
• 关键词: Modulating; Protein; Interactions; Disease

Most diseases are driven by protein-protein interactions often with few/no greasy pockets to fit small molecule drugs. Innovative approaches to new drugs are needed for these proteins. This project combines chemistry, biochemistry and pharmacology to create new drug leads, new knowledge on drug action and disease development at gene, protein, cell, animal levels, and aims to trial new drug leads in preclinical and eventually clinical tests in inflammatory and metabolic diseases, pain and cancer.

大多数疾病是由蛋白质-蛋白质相互作用驱动的，通常只有很少或没有油腻的口袋适合小分子药物。对于这些蛋白质，需要创新的药物开发方法。该项目将化学、生物化学和药理学结合在一起，在基因、蛋白质、细胞和动物水平上创造新的药物线索、药物作用和疾病发展的新知识，并旨在在炎症和代谢性疾病、疼痛和癌症的临床前和最终临床试验中试验新的药物线索。