Compressing small peptides for cell absorption

压缩小肽以供细胞吸收

• 批准号: DP180103244
• 负责人: Prof David Fairlie
• 金额: $ 40.43万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP180103244
• 关键词: Compressing; small; peptides; cell; absorption

This project aims to understand how to make small structured peptides cell-permeable. Short peptides matching bioactive protein surfaces have no structure in water and do not enter cells, where most biological reactions occur. This project will compress peptides into very small coiled structures and systematically vary cyclic restraints, physicochemical properties and location of components to increase cell uptake by different mechanisms. An expected outcome is new knowledge for predicting structures that make peptides cell-permeable without membrane damage. A new capacity to rationally downsize proteins to small, cell-permeable, structured peptides is anticipated to permit many new biological and industrial applications.

该项目旨在了解如何使小结构肽具有细胞渗透性。与生物活性蛋白表面相匹配的短肽在水中没有结构，也不会进入细胞，而大多数生物反应都发生在细胞中。该项目将肽压缩成非常小的卷曲结构，并系统地改变循环限制，理化性质和组分的位置，以通过不同的机制增加细胞摄取。一个预期的结果是新的知识，预测结构，使肽细胞渗透性没有膜损伤。一个新的能力，合理地缩小蛋白质的小，细胞可渗透的，结构化的肽，预计将允许许多新的生物和工业应用。