Capturing New Drugs That Selectively Modulate PAR2 Signaling Pathways
Capturing New Drugs That Selectively Modulate PAR2 Signaling Pathways
批准号:
nhmrc : 1047759
负责人:
Prof David Fairlie
金额:
$31.28万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2013
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2013-01-01 至 2015-12-31
中文摘要
点击翻译按钮获取中文摘要
英文摘要
Infection and tissue damage provoke acute inflammatory responses that sometimes continue unchecked, leading to different kinds of debilitating inflammatory diseases and cancers. We have discovered a new class of drugs that bind to a new target on human cells and block undesirable prolonged inflammatory responses. This project tests a new strategy to produce 'cleaner' drugs that act more selectively with fewer side effects against a new target in the treatment of arthritis and other inflammatory diseases, diet-induced obesity and cancers.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Super-resolution platform to accelerate biological and molecular research
-
批准号:LE240100134
-
项目类别:Linkage Infrastructure, Equipment and Facilities
-
资助金额:$53.09万
-
财政年份:2024
-
负责人:Prof David Fairlie
-
依托单位:
Compressing small peptides for cell absorption
-
批准号:DP180103244
-
项目类别:Discovery Projects
-
资助金额:$40.43万
-
财政年份:2018
-
负责人:Prof David Fairlie
-
依托单位:
Combating infectious diseases by harnessing macrophage functions
-
批准号:nhmrc : GNT1125316
-
项目类别:Project Grants
-
资助金额:$68.82万
-
财政年份:2017
-
负责人:Prof David Fairlie
-
依托单位:
Modulating Protein-Protein Interactions In Disease
-
批准号:nhmrc : GNT1117017
-
项目类别:Research Fellowships
-
资助金额:$86.39万
-
财政年份:2017
-
负责人:Prof David Fairlie
-
依托单位:
Combating infectious diseases by harnessing macrophage functions
-
批准号:nhmrc : 1125316
-
项目类别:Project Grants
-
资助金额:$46.96万
-
财政年份:2017
-
负责人:Prof David Fairlie
-
依托单位:
Modulating Protein-Protein Interactions In Disease
-
批准号:nhmrc : 1117017
-
项目类别:Research Fellowships
-
资助金额:$59.07万
-
财政年份:2017
-
负责人:Prof David Fairlie
-
依托单位:
Engineering peptides into superglues selective for target proteins
-
批准号:DP160104442
-
项目类别:Discovery Projects
-
资助金额:$37.48万
-
财政年份:2016
-
负责人:Prof David Fairlie
-
依托单位:
Engineering Cyclic Peptides For Oral Bioavailability
-
批准号:DP150104609
-
项目类别:Discovery Projects
-
资助金额:$34.7万
-
财政年份:2015
-
负责人:Prof David Fairlie
-
依托单位:
Development of antimalarial histone deacetylase inhibitors
-
批准号:nhmrc : GNT1093378
-
项目类别:Development Grants
-
资助金额:$55.68万
-
财政年份:2015
-
负责人:Prof David Fairlie
-
依托单位:
Development of antimalarial histone deacetylase inhibitors
-
批准号:nhmrc : 1093378
-
项目类别:Development Grants
-
资助金额:$38.25万
-
财政年份:2015
-
负责人:Prof David Fairlie
-
依托单位:
Downsizing A Human Protein To Modulate Inflammatory Diseases
-
批准号:nhmrc : 1084018
-
项目类别:Project Grants
-
资助金额:$34.46万
-
财政年份:2015
-
负责人:Prof David Fairlie
-
依托单位:
Anti-Parasitic Drug Discovery in Epigenetics
-
批准号:nhmrc : 1074016
-
项目类别:Targeted Calls
-
资助金额:$18.15万
-
财政年份:2014
-
负责人:Prof David Fairlie
-
依托单位:
Downsizing proteins to equipotent small molecules that activate cells
-
批准号:DP130100629
-
项目类别:Discovery Projects
-
资助金额:$34.11万
-
财政年份:2013
-
负责人:Prof David Fairlie
-
依托单位:
Small Molecule Modulators of Complement in Metabolism and Obesity
-
批准号:nhmrc : 1028423
-
项目类别:Project Grants
-
资助金额:$45.53万
-
财政年份:2012
-
负责人:Prof David Fairlie
-
依托单位:
Flaviviral proteases as viable targets for antiinfective drugs
-
批准号:nhmrc : 1025883
-
项目类别:Project Grants
-
资助金额:$41.39万
-
财政年份:2012
-
负责人:Prof David Fairlie
-
依托单位:
Research Fellowship
-
批准号:nhmrc : 1027369
-
项目类别:Research Fellowships
-
资助金额:$55.8万
-
财政年份:2012
-
负责人:Prof David Fairlie
-
依托单位:
Profiling global inflammatory signatures for GPCRs in human macrophages
-
批准号:nhmrc : 1030169
-
项目类别:Project Grants
-
资助金额:$45.86万
-
财政年份:2012
-
负责人:Prof David Fairlie
-
依托单位:
Protein And Peptide Alpha Turns
-
批准号:DP1096290
-
项目类别:Discovery Projects
-
资助金额:$25.08万
-
财政年份:2010
-
负责人:Prof David Fairlie
-
依托单位:
Protease Activated Receptor 2 Antagonist In Inflammatory Disease
-
批准号:nhmrc : 1000745
-
项目类别:NHMRC Development Grants
-
资助金额:$41.43万
-
财政年份:2010
-
负责人:Prof David Fairlie
-
依托单位:
Common hot spots in protein-activated GPCRs enable discovery of new ligands for mapping of G-protein signalling pathways
-
批准号:DP1093245
-
项目类别:Discovery Projects
-
资助金额:$62.7万
-
财政年份:2010
-
负责人:Prof David Fairlie
-
依托单位:
海外基金