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FLUTAMIDE AND GNRH SECRETION IN PCOS AND NORMALS

FLUTAMIDE AND GNRH SECRETION IN PCOS AND NORMALS
PCOS 和正常人中氟他胺和 GNRH 的分泌
批准号:
6307487
负责人:
John C Marshall
金额:
$2.81万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1999
资助国家:
美国
项目状态:
已结题
起止时间:
1999-12-01 至 2001-02-28

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中文摘要
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英文摘要
This study examines the effects of flutamide, an androgen blocker, on progesterone suppression of LH pulses in women with polycystic ovary syndrome and normal women. GnRH/LH pulsatility is monitored by 13-hour blood sampling every 10 minutes. The subjects then take flutamide for one month, then come back to repeat the testing above. They then take flutamide, estrogen, and progesterone for one week and repeat the testing again. We hope to learn whether GnRH pulse generator activity is altered by androgen blockade and if E2 and P are now more effective in suppressing LH pulse frequency in PCOS.
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CRR LIGAND ASSAY AND ANALYSIS CORE
  • 批准号:
    10017063
  • 项目类别:
  • 资助金额:
    $44.4万
  • 财政年份:
    2019
  • 负责人:
    John C Marshall
  • 依托单位:
Clinical and Basic Studies in Polycystic Ovarian Syndrome
  • 批准号:
    8081160
  • 项目类别:
  • 资助金额:
    $4.7万
  • 财政年份:
    2010
  • 负责人:
    John C Marshall
  • 依托单位:
METFORMIN AND SENSITIVITY OF GNRH PULSE GENERATOR SUPPRESSION IN HYPERANDROGEMIA
  • 批准号:
    8167194
  • 项目类别:
  • 资助金额:
    $4.01万
  • 财政年份:
    2010
  • 负责人:
    John C Marshall
  • 依托单位:
ANDROGEN BLOCKADE AND SENSITIVITY OF THE GNRH PULSE GENERATOR
  • 批准号:
    8167167
  • 项目类别:
  • 资助金额:
    $1.2万
  • 财政年份:
    2010
  • 负责人:
    John C Marshall
  • 依托单位:
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