FLUTAMIDE AND GNRH SECRETION IN PCOS AND NORMALS

PCOS 和正常人中氟他胺和 GNRH 的分泌

• 批准号: 6307487
• 负责人: John C Marshall
• 金额: $ 2.81万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2001-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6307487
• 关键词: androgen inhibitor; clinical research; female; gonadotropin releasing factor; hormone regulation /control mechanism; human subject; hypothalamic pituitary axis; luteinizing hormone; menstrual cycle; pituitary gonadal axis; polycystic ovary syndrome

This study examines the effects of flutamide, an androgen blocker, on progesterone suppression of LH pulses in women with polycystic ovary syndrome and normal women. GnRH/LH pulsatility is monitored by 13-hour blood sampling every 10 minutes. The subjects then take flutamide for one month, then come back to repeat the testing above. They then take flutamide, estrogen, and progesterone for one week and repeat the testing again. We hope to learn whether GnRH pulse generator activity is altered by androgen blockade and if E2 and P are now more effective in suppressing LH pulse frequency in PCOS.

本研究探讨了雄激素阻断剂氟替卡松对多囊卵巢综合征妇女和正常妇女LH脉冲的孕酮抑制的影响。通过每10分钟采集13小时血样监测GnRH/LH脉动。然后受试者服用氟替卡松一个月，然后回来重复上述测试。然后他们服用氟替卡松，雌激素和黄体酮一周，并再次重复测试。我们希望了解雄激素阻断是否会改变GnRH脉冲发生器的活性，以及E2和P现在是否能更有效地抑制PCOS患者的LH脉冲频率。