BEHAVIORAL & VETERINARY APPROACHES TO PRIMATE BREEDING

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• 批准号: 6311803
• 负责人: FRANS B DE WAAL
• 金额: $ 3.85万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1976
• 资助国家: 美国
• 起止时间: 1976-06-01 至 2001-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6311803
• 关键词: Mammalia; behavioral /social science research tag; cognition; nervous system; psychology

Recent studies in rhesus monkeys have demonstrated an association of early developmental stress and decreased plasma measures of serotonin with increased incidence of maladaptive behaviors including aggression, poor impulse control and increased levels of alcohol self-administration. Similar relationships between plasma serotonin and maladaptive behaviors have also been described in humans. The objective of these experiments is to examine the potential role of reduced brain serotonin levels in the development of impulsive behavioral patterns in juvenile rhesus monkeys. We compare juvenile monkeys reared in peer groups with mother reared monkeys who are either intact or have been depleted of brain serotonin following administration of neurotoxic doses of MDMA. Initial comparisons focus on interactions in structured play groups, and performance in a computerized battery of cognitive tasks. Cognitive testing examines memory, attention, and executive function, as well as tasks designed to assess social cognition. Subsequent studies will examine the interaction of decreased central serotonin with the effects of acute alcohol administration, and the incidence of excessive alcohol self-administration in a free-choice ethanol self-administration paradigm. In the last phase of the study we will examine the potential role of brain vasopressinergic neural substrates in the behavioral differences associated with rearing and serotonin. FUNDING URC / Emory University $30,000 4/01/98 - 4/01/99 PUBLICATIONS None P51RR00165-38 1/1/98 - 12/31/98 Yerkes Regional Primate Research Center

最近对恒河猴的研究证明了这种关联 早期发育应激和血浆测量值降低 血清素会增加适应不良行为的发生率，包括 攻击性、冲动控制能力差和酒精含量增加 自我管理。 血浆血清素之间的相似关系 人类也有适应不良的行为。 这 这些实验的目的是检验潜在的作用 冲动发展过程中大脑血清素水平降低 幼年恒河猴的行为模式。 我们比较少年 猴子与同辈群体中的母亲养育的猴子一起长大 要么完好无损，要么已耗尽大脑血清素 施用神经毒性剂量的 MDMA。 初步比较重点 结构化游戏小组中的互动以及游戏中的表现 计算机化的认知任务电池组。 认知测试检查 记忆、注意力和执行功能，以及设计的任务 评估社会认知。 后续研究将检验 中枢血清素减少与急性应激反应的相互作用 饮酒和过量饮酒的发生率 自由选择乙醇自我管理中的自我管理 范例。 在研究的最后阶段，我们将检查 脑血管加压素能神经底物的潜在作用 与饲养和血清素相关的行为差异。 资金 URC / 埃默里大学 $30,000 4/01/98 - 4/01/99 出版物 无 P51RR00165-38 1/1/98 - 12/31/98 耶克斯地区灵长类动物研究 中心