LIVING LINKS CENTER FOR STUDY OF APE & HUMAN EVOLUTION

这些正在进行的研究继续测试工作假设 生长激素诱导的胰岛素样生长因子-I的增加 （IGF-I）调节青春期的克里思，促进成年人的生育能力 女性 IGF-I的给药由 Genentech Inc.生长抑素类似物奥曲肽， 由山德士制药慷慨提供 主要研究结果包括 1)IGF-I给药加速女性青春期的克里思 第一次排卵时的年龄提前; 2）IGF-I给药 增强垂体对促黄体生成素（LH）分泌的反应 兴奋性氨基酸类似物NMDA在月经后期女性; 3)IGF-I补充或生长抑素治疗 类似物（降低内源性IGF-I）影响的参数 成年女性的排卵周期; 4）IGF-I补充 用生长抑素类似物治疗也不影响垂体 LH分泌对LH释放激素类似物的反应， 青春期后或成年女性; 5）IGF-I增加血清 IGFBP-3的浓度，有效地增加其生物活性， 减缓降解。 这些数据表明， IGF-I和IGFBP-3在调节女性青春期发育中起重要作用 但不参与维持成年人的生育能力。 资助NIH / NICHD $87，692 4/01/82 - 11/30/98出版物Wilson， 法医生长激素-胰岛素样生长因子-I的调节 雌二醇对发育期和成年猴的胰岛素样生长因子-I轴的影响 替代和补充IGF-I。 J. of Clin. Endocrinol. Metab. 83：2018-2028，1998年。 Wilson，M.E.过早升高， 胰岛素样生长因子-I促进恒河猴首次排卵 猴子 J. Endocrinol. 158：247-257，1998. Wilson，M.E.的影响 雌二醇和外源性胰岛素样生长因子（IGF）-I对 IGF-1轴在生长激素抑制和拮抗作用J。 年. Metab. 83：4013-4021，1998. Wilson，M.E.连续 皮下输注，而不是每天两次注射 胰岛素样生长（IGF）-I更有效地提高血清IGF 结合（IGFBP）-3在雌性猴子。 EUR. J. Endocrinol. （在 Press）。 Wilson，M.E.和雷基，S. IGF-I但不是IGF-I变体 长R3 IGF-I增加青春期猴的血清IGFBP-3。 增长 Hormone & IGF Res.（In press）. P51 RR 00165 -38 1998年1月1日至1998年12月31日 耶基斯地区灵长类动物研究中心

These ongoing studies continued to test the working hypothesis that growth hormone-induced increases in insulin-like growth factor-I (IGF-I) regulates the tempo of puberty and promotes fertility in adult females. IGF-I for administration was generously provided by Genentech Inc. and the somatostatin analogue, Octreotide, was generously provided by Sandoz Pharmaceuticals. Major findings include 1) IGF-I administration accelerates the tempo of puberty in female monkeys, advancing the age at 1st ovulation; 2) IGF-I administration enhanced the pituitary response in luteinizing hormone (LH) secretion to the excitatory amino acid analog, NMDA in post menarchial females; 3) neither IGF-I supplementation nor treatment with a somatostatin analogue (which lowers endogenous IGF-I) affected parameters of ovulatory cycles in adult females; 4) neither IGF-I supplementation nor treatment with a somatostatin analogue affected the pituitary response in LH secretion to an LH re leasing hormone analog in post-pubertal or adult females; 5) IGF-I increases serum concentrations of IGFBP-3, effectively increasing its bioactivity by slowing degradation. These data indicate that peripheral increases in IGF-I and IGFBP-3 play an important role regulating puberty in females but is not involved in the maintenance of fertility in adults. FUNDING NIH / NICHD $87,692 4/01/82 - 11/30/98 PUBLICATIONS Wilson, M.E. Regulation of the growth hormone - insulin-like growth factor-I (IGF-I) axis in developing and adult monkeys is affected by estradiol replacement and supplementation with IGF-I. J. of Clin. Endocrinol. Metab. 83:2018-2028, 1998. Wilson, M.E. Premature elevation in insulin-like growth factor-I advances first ovulation in rhesus monkeys. J. Endocrinol. 158:247-257, 1998. Wilson, M.E. Effects of estradiol and exogenous insulin-like growth factor (IGF) -I on the IGF-I axis during GH inhibition and antagonism J. of Clin. Endocrinol. Metab. 83:4013-4021, 1998. Wilson, M.E. Continuous subcutaneous infusion rather than twice daily injections of insulin-like growth (IGF) -I more effectively elevates serum IGF binding (IGFBP) -3 in female monkeys. Eur. J. Endocrinol. (In press). Wilson, M.E. and Lackey, S. IGF-I but not the IGF-I variant Long R3 IGF-I increases serum IGFBP-3 in adolescent monkeys. Growth Hormone & IGF Res. (In press). P51 RR00165-38 1/1/98 - 12/31/98 Yerkes Regional Primate Research Center