GLUCOKINASE GENE EXPRESSION IN PANCREATIC BETA CELL
GLUCOKINASE GENE EXPRESSION IN PANCREATIC BETA CELL
批准号:
6380649
负责人:
MARK A MAGNUSON
金额:
$21.34万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1990
资助国家:
美国
项目状态:
已结题
起止时间:
1990-06-01 至 2002-06-30
关键词:
biological models blood glucose enzyme activity gene expression gene targeting genetically modified animals glucokinase glucose metabolism homeostasis hyperglycemia immunocytochemistry laboratory mouse liver disorder molecular pathology noninsulin dependent diabetes mellitus northern blottings pancreatic islet function polymerase chain reaction radioimmunoassay western blottings
中文摘要
葡萄糖激酶(GK)在葡萄糖稳态中起重要作用。在
英文摘要
Glucokinase (GK) plays an essential role in glucose homeostasis. In
humans, mutations in this enzyme cause both maturity onset diabetes of
youth, type 2 (MODY-2) and persistant hyperinsulinemic hypoglycemia of
infancy (PHHI). Although GK gene mutations are one of only a few
genetically-defined causes of diabetes, we do not yet fully understood
how mutations in this gene actually alter the plasma glucose
concentration.
This is a proposal to make use of novel lines transgenic and gene-
altered mice to learn more about the cell-specific roles of glucokinase
(GK) in glucose homeostasis and about adaptive responses that occur in
response to acute and chronic alternations in the plasma glucose
concentration. Aim 1 will define the tissue-specific functions of GK
in glucose homeostasis by selectively removing it from different cell
types using a Cre/LoxP strategy. Aim 2 will develop mice with inducible
defects in either hepatic glucose utilization and/or beta cell insulin
secretion, and characterize the adaptations that occur in response to
both an acute loss of either hepatic or islet GK. Together, these
studies will provide fundamental new insights into the molecular
pathogenesis MODY-2 as well adaptations that occur in response to
hyperglycemia. Thus, these studies are also relevant to the
pathogenesis and treatment of Type 2 diabetes mellitus.
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Coordinating Center for Beta Cell Biology Consortium
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批准号:8121183
-
项目类别:
-
资助金额:$11.51万
-
财政年份:2010
-
负责人:MARK A MAGNUSON
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依托单位:
Transgenic Mouse
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批准号:8180600
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项目类别:
-
资助金额:$9.44万
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财政年份:2010
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负责人:MARK A MAGNUSON
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依托单位:
Genetic control of pancreatic endocrine cell development
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批准号:7993178
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项目类别:
-
资助金额:$133.62万
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财政年份:2010
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负责人:MARK A MAGNUSON
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依托单位:
Genetic control of pancreatic endocrine cell development
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批准号:8717642
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项目类别:
-
资助金额:$10.0万
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财政年份:2010
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负责人:MARK A MAGNUSON
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依托单位:
Genetic control of pancreatic endocrine cell development
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批准号:8522192
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项目类别:
-
资助金额:$124.36万
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财政年份:2010
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负责人:MARK A MAGNUSON
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依托单位:
Genetic control of pancreatic endocrine cell development
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批准号:8144905
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项目类别:
-
资助金额:$129.87万
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财政年份:2010
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负责人:MARK A MAGNUSON
-
依托单位:
Genetic control of pancreatic endocrine cell development
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批准号:8316316
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项目类别:
-
资助金额:$129.87万
-
财政年份:2010
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负责人:MARK A MAGNUSON
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依托单位:
Coordinating Center for Beta Cell Biology Consortium
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批准号:8010566
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项目类别:
-
资助金额:$12.96万
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财政年份:2010
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负责人:MARK A MAGNUSON
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依托单位:
Coordinating Center for Beta Cell Biology Consortium
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批准号:7825081
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项目类别:
-
资助金额:$259.59万
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财政年份:2009
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负责人:MARK A MAGNUSON
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依托单位:
EFFECTS OF LIVER SPECIFIC KNOCKOUT OF PEPCK ON GLUCOSE METABOLISM
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批准号:7724113
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项目类别:
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资助金额:$1.05万
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财政年份:2008
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负责人:MARK A MAGNUSON
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依托单位:
EFFECTS OF LIVER SPECIFIC KNOCKOUT OF PEPCK ON GLUCOSE METABOLISM
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批准号:7600847
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项目类别:
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资助金额:$1.51万
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财政年份:2007
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负责人:MARK A MAGNUSON
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依托单位:
EFFECTS OF LIVER SPECIFIC KNOCKOUT OF PEPCK ON GLUCOSE METABOLISM
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批准号:7357890
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项目类别:
-
资助金额:$1.17万
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财政年份:2006
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负责人:MARK A MAGNUSON
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依托单位:
EFFECTS OF LIVER SPECIFIC KNOCKOUT OF PEPCK ON GLUCOSE METABOLISM
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批准号:7180729
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项目类别:
-
资助金额:$2.1万
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财政年份:2005
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负责人:MARK A MAGNUSON
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依托单位:
Coordinating Center for Beta Cell Biology Consortium
-
批准号:8525392
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项目类别:
-
资助金额:$357.0万
-
财政年份:2005
-
负责人:MARK A MAGNUSON
-
依托单位:
Coordinating Center for Beta Cell Biology Consortium
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批准号:8326734
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项目类别:
-
资助金额:$370.0万
-
财政年份:2005
-
负责人:MARK A MAGNUSON
-
依托单位:
Coordinating Center for Beta Cell Biology Consortium
-
批准号:7684082
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项目类别:
-
资助金额:$342.06万
-
财政年份:2005
-
负责人:MARK A MAGNUSON
-
依托单位:
Coordinating Center for Beta Cell Biology Consortium
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批准号:7913613
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项目类别:
-
资助金额:$523.91万
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财政年份:2005
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负责人:MARK A MAGNUSON
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依托单位:
Endocrine cell induction during pancreas
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批准号:7056487
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项目类别:
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资助金额:$36.46万
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财政年份:2005
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负责人:MARK A MAGNUSON
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依托单位:
Administrative Core
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批准号:7056498
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项目类别:
-
资助金额:$7.6万
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财政年份:2005
-
负责人:MARK A MAGNUSON
-
依托单位:
Coordinating Center for Beta Cell Biology Consortium
-
批准号:7500228
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项目类别:
-
资助金额:$43.23万
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财政年份:2005
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负责人:MARK A MAGNUSON
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依托单位:
海外基金