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BINDING OF CHARGED PEPTIDES & PROTEINS TO LIPID BILAYERS

BINDING OF CHARGED PEPTIDES & PROTEINS TO LIPID BILAYERS
带电肽的结合
批准号：
6314220
负责人：
BARRY H HONIG
金额：
$4.36万
依托单位：
COLUMBIA UNIV NEW YORK MORNINGSIDE
依托单位国家：
美国
项目类别：
财政年份：
2000
资助国家：
美国
项目状态：
已结题
起止时间：
2000-05-05 至 2002-04-30
来源：
https://reporter.nih.gov/project-details/6314220
关键词：
biological products biomedical resource computers proteins statistics /biometry technology /technique

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Thephysicalforcesthatdeterminethebindingofproteinstothe surface of membranes is a problem of central biological importance through its relationship to signal transduction pathways. We are using continuum electrostatics to study this problem in collaboration with the group of Stuart McLaughlin who is measuring binding affinities as a function of lipid composition and salt. This work has been carried out using a parallel version of DelPhi written by Nir Ben-Tal and implemented on the CM-5.
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