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BINDING OF CHARGED PEPTIDES & PROTEINS TO LIPID BILAYERS

BINDING OF CHARGED PEPTIDES & PROTEINS TO LIPID BILAYERS
带电肽的结合
批准号：
6314220
负责人：
BARRY H HONIG
金额：
$4.36万
依托单位：
COLUMBIA UNIV NEW YORK MORNINGSIDE
依托单位国家：
美国
项目类别：
财政年份：
2000
资助国家：
美国
项目状态：
已结题
起止时间：
2000-05-05 至 2002-04-30
来源：
https://reporter.nih.gov/project-details/6314220
关键词：
biological products biomedical resource computers proteins statistics /biometry technology /technique

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中文摘要
翻译
决定蛋白质与表面结合的物理力 膜是一个重要的生物学问题， 与信号转导通路的关系。 我们使用的是连续体 与该小组合作研究这个问题 斯图尔特·麦克劳克林在测量结合亲和力 脂质成分和盐。 这项工作是使用一个 由Nir Ben-Tal编写并在 CM-5
英文摘要
Thephysicalforcesthatdeterminethebindingofproteinstothe surface of membranes is a problem of central biological importance through its relationship to signal transduction pathways. We are using continuum electrostatics to study this problem in collaboration with the group of Stuart McLaughlin who is measuring binding affinities as a function of lipid composition and salt. This work has been carried out using a parallel version of DelPhi written by Nir Ben-Tal and implemented on the CM-5.
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