How do our gut bacteria communicate with the brain? (SSA)

最近的研究表明，肠道细菌可以影响神经系统的结果，改变行为，并可能影响自闭症或帕金森病等神经系统疾病的发病和/或严重程度。然而，肠道微生物如何影响神经功能和行为的确切机制在很大程度上仍然未知。该博士项目将采用跨学科的方法，包括非生物啮齿动物模型，以破译黏液降解肠道细菌物种在脑功能和神经发生中的作用。该项目将提供肠道-微生物群-大脑联系的机制见解，并有助于合理设计基于微生物群的大脑疾病治疗策略。

Recent studies have suggested that gut bacteria can impact neurological outcomes, altering behaviour and potentially affecting the onset and/or severity of nervous system disorders such as autism or Parkinson's diseases. However the precise mechanisms of how the intestinal microbes impact neurological function and behaviour remain largely unknown. This PhD project will use a trans-disciplinary approach including gnotobiotic rodent models to decipher the role of mucin-degrading gut bacteria species on brain function and neurogenesis. This project will provide mechanistic insights into gut-microbiome-brain connections and help rationally design microbiota-based strategies for brain disorders.