Neurobehavior, Neuroendocrinology, and Genetics of AD

AD 的神经行为、神经内分泌学和遗传学

• 批准号: 6747779
• 负责人: SUZANNE CRAFT
• 金额: $ 40.47万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-06-15 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6747779
• 关键词: Neurobehavior; Neuroendocrinology; Genetics; AD

DESCRIPTION (provided by applicant): This application seeks a renewal of NIA T32 AG00258 entitled "Neurobehavior, Neuroendocrinology, and Genetics of AD". By the end of our first funding cycle our program will have supported 12 post-doctoral trainees (6 with M.D. degrees and 6 with Ph.D. degrees). Our inaugural training efforts have been successful, as evidenced by the accomplishments of our trainees, as well as by our ability to attract qualified minority candidates and physician trainees to our program. Given our initial success, and the increase in demand for trainee support, we request an expansion of our program from five to seven trainee positions. In the next funding cycle, we will continue to provide post-doctoral training in clinical research regarding the neurobehavior, neuroendocrinology, and neurogenetics of Alzheimer's Disease (AD) and related dementias. In particular, the program will focus on training clinical researchers capable of translating critical findings from basic science into hypotheses regarding the etiology, pathophysiology, and treatment of AD. Furthermore, clinical researchers will receive specialized training in two areas of study, neuroendocrinology and neurogenetics that hold promise for increasing our understanding of the pathogenesis of AD and for developing new therapeutic approaches. These areas are not typically emphasized in graduate training of psychiatrists, neurologists, or neuropsychologists. However, recent advances have underscored the importance of genetic factors such as amyloid precursor protein and presenilin mutations, and apolipoprotein(e) genotype. Neuroendocrine factors such as disruptions of lipid and insulin metabolism, inflammation, and glucocorticoid status may also play an important pathogenetic role in modifying the effects of AD susceptibility genes, thereby affecting the neuropsychologic expression of AD. Clinical investigators capable of bridging the fields of neurogenetics, neuropsychology, and neuroendocrinotogy will be needed to disentangle and define these potentially critical interactions. The program is supported by the rich and interactive research environment of the University of Washington and Veterans Affairs Puget Sound Health Care System, where a critical mass of faculty conduct both basic science and clinical research in the neuroendocrinology and neurogenetics of AD. The ADRC at the UW will also serve as a resource for faculty and trainees. Although there is a long-standing commitment to aging training at our institution, our proposed program is unique in its interdisciplinary nature and focus on clinical translational research in AD and related conditions. As such, it will provide a much-needed approach to the training of clinical research scientists whose work will address these complex disorders.

描述（由申请人提供）：本申请寻求更新NIA T32 AG00258，标题为“AD的神经行为，神经内分泌学和遗传学”。到第一个资助周期结束时，我们的项目将支持12名博士后学员（6名拥有医学博士学位，6名拥有博士学位）。我们最初的培训工作是成功的，从我们的学员取得的成就，以及我们吸引合格的少数民族候选人和医生学员到我们的项目的能力来看，都证明了这一点。鉴于我们最初的成功，以及对培训生支持需求的增加，我们要求将我们的项目从5个扩展到7个培训生职位。