Neurobehavior, Neuroendocrinology, and Genetics of AD

AD 的神经行为、神经内分泌学和遗传学

• 批准号: 6887726
• 负责人: SUZANNE CRAFT
• 金额: $ 41.89万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-06-15 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6887726
• 关键词: Neurobehavior; Neuroendocrinology; Genetics; AD

DESCRIPTION (provided by applicant): This application seeks a renewal of NIA T32 AG00258 entitled "Neurobehavior, Neuroendocrinology, and Genetics of AD". By the end of our first funding cycle our program will have supported 12 post-doctoral trainees (6 with M.D. degrees and 6 with Ph.D. degrees). Our inaugural training efforts have been successful, as evidenced by the accomplishments of our trainees, as well as by our ability to attract qualified minority candidates and physician trainees to our program. Given our initial success, and the increase in demand for trainee support, we request an expansion of our program from five to seven trainee positions. In the next funding cycle, we will continue to provide post-doctoral training in clinical research regarding the neurobehavior, neuroendocrinology, and neurogenetics of Alzheimer's Disease (AD) and related dementias. In particular, the program will focus on training clinical researchers capable of translating critical findings from basic science into hypotheses regarding the etiology, pathophysiology, and treatment of AD. Furthermore, clinical researchers will receive specialized training in two areas of study, neuroendocrinology and neurogenetics that hold promise for increasing our understanding of the pathogenesis of AD and for developing new therapeutic approaches. These areas are not typically emphasized in graduate training of psychiatrists, neurologists, or neuropsychologists. However, recent advances have underscored the importance of genetic factors such as amyloid precursor protein and presenilin mutations, and apolipoprotein(e) genotype. Neuroendocrine factors such as disruptions of lipid and insulin metabolism, inflammation, and glucocorticoid status may also play an important pathogenetic role in modifying the effects of AD susceptibility genes, thereby affecting the neuropsychologic expression of AD. Clinical investigators capable of bridging the fields of neurogenetics, neuropsychology, and neuroendocrinotogy will be needed to disentangle and define these potentially critical interactions. The program is supported by the rich and interactive research environment of the University of Washington and Veterans Affairs Puget Sound Health Care System, where a critical mass of faculty conduct both basic science and clinical research in the neuroendocrinology and neurogenetics of AD. The ADRC at the UW will also serve as a resource for faculty and trainees. Although there is a long-standing commitment to aging training at our institution, our proposed program is unique in its interdisciplinary nature and focus on clinical translational research in AD and related conditions. As such, it will provide a much-needed approach to the training of clinical research scientists whose work will address these complex disorders.

描述（由申请人提供）：本申请寻求更新NIA T32 AG00258，标题为“AD的神经行为、神经内分泌学和遗传学”。到我们的第一个资助周期结束时，我们的计划将支持12名博士后学员（6名拥有医学博士学位）。6人获博士学位度）。我们的就职培训工作取得了成功，我们的学员的成就，以及我们吸引合格的少数民族候选人和医生学员到我们的计划的能力证明。鉴于我们最初的成功，以及对培训生支持需求的增加，我们要求将我们的计划从5个培训生职位扩大到7个。 在下一个资助周期，我们将继续提供有关阿尔茨海默病（AD）和相关痴呆症的神经行为学，神经内分泌学和神经遗传学临床研究的博士后培训。特别是，该计划将侧重于培训能够将基础科学的关键发现转化为有关AD病因学，病理生理学和治疗的假设的临床研究人员。此外，临床研究人员将接受两个研究领域的专门培训，神经内分泌学和神经遗传学，这有望增加我们对AD发病机制的理解，并开发新的治疗方法。 这些领域在精神科医生、神经科医生或神经心理学家的研究生培训中通常不被强调。 然而，最近的进展强调了遗传因素的重要性，如淀粉样前体蛋白和早老素突变，载脂蛋白（e）基因型。神经内分泌因素如脂质和胰岛素代谢的破坏、炎症和糖皮质激素状态也可能在改变AD易感基因的作用中发挥重要的致病作用，从而影响AD的神经心理学表达。临床研究人员能够桥接神经遗传学，神经心理学和神经内分泌学领域将需要解开和定义这些潜在的关键相互作用。 该计划得到了华盛顿大学和退伍军人事务部普吉特海湾医疗保健系统丰富的互动研究环境的支持，在那里，大量的教师在AD的神经内分泌学和神经遗传学方面进行基础科学和临床研究。华盛顿大学的ADRC也将作为教师和学员的资源。虽然我们的机构长期致力于老龄化培训，但我们提出的计划在其跨学科性质方面是独一无二的，并专注于AD和相关疾病的临床转化研究。因此，它将为临床研究科学家的培训提供急需的方法，这些科学家的工作将解决这些复杂的疾病。