Neurobehavior, Neuroendocrinology, and Genetics of AD

AD 的神经行为、神经内分泌学和遗传学

基本信息

  • 批准号:
    8245044
  • 负责人:
  • 金额:
    $ 38.78万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1999
  • 资助国家:
    美国
  • 起止时间:
    1999-06-15 至 2014-04-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): This application seeks a renewal of NIA T32 AG00258 entitled "Neurobehavior, Neuroendocrinology, and Genetics of AD". By the end of our second funding cycle our program will have supported 27 post-doctoral trainees (12 with M.D. degrees, 3 of whom also have PhDs, and 15 with Ph.D. degrees). Our training efforts have been successful, as evidenced by the accomplishments of our trainees, as well as by our ability to attract qualified candidates and physician trainees to our program. In the next funding cycle, we will continue to provide post-doctoral training in clinical research regarding the neurobehavior, neuroendocrinology, and neurogenetics of Alzheimer's disease (AD) and related dementias. In particular, the program will focus on training clinical researchers capable of translating critical findings from basic science into hypotheses regarding the etiology, pathophysiology, and treatment of AD. Furthermore, clinical researchers will receive specialized training in two areas of study, neuroendocrinology and neurogenetics, that hold promise for increasing our understanding of the pathogenesis of AD and for developing new therapeutic approaches. These areas are not typically emphasized in graduate training of psychiatrists, neurologists, or neuropsychologists. However, recent advances have underscored the importance of genetic factors such as amyloid precursor protein and presenilin mutations, and apolipoprotein e genotype. Neuroendocrine factors such as disruptions of lipid, insulin and glucose metabolism, inflammation, and glucocorticoid status may also play an important pathogeneticjole in modifying the effects of AD susceptibility genes, thereby affecting the neuropsychologic expression of AD. Clinical investigators capable of bridging the fields of neurogenetics, neuropsychology, and neuroendocrinology will be needed to disentangle and define these potentially critical interactions. The program is supported by the rich and interactive research environment of the University of Washington and Veterans Affairs Puget Sound Health Care System, where a critical mass of faculty conduct both basic science and clinical research in the neuroendocrinology and neurogenetics of AD. The ADRC at the UWwill also serve as a resource for faculty and trainees. Although there is a long-standing commitment to aging training at our institution, our proposed program is unique in its interdisciplinary nature and focus on clinical translational research in AD and related conditions. As such, it will provide a much-needed approach to the training of clinical research scientists whose work will address these complex disorders. RELEVANCE: Our program trains researchers who are able to translate findings from basic science into clinical models of Alzheimer's disease and other dementias, and thereby facilitate the development of new treatments for these challenging diseases. In particular, the program focuses on the interactive role played by genetic and metabolic factors such as diabetes and stress in increasing the risk of dementia. These factors are highly prevalent in our society, and a better understanding of their role may lead to new treatments and strategies for preventing dementia or delaying its onset.
描述(由申请人提供):本申请寻求更新NIA T32 AG00258,标题为“AD的神经行为、神经内分泌学和遗传学”。到我们的第二个资助周期结束时,我们的计划将支持27名博士后学员(12名拥有医学博士学位)。学位,其中3人还拥有博士学位,15人拥有博士学位。度)。我们的培训工作是成功的,我们的学员的成就,以及我们吸引合格的候选人和医生学员到我们的计划的能力证明。在下一个资助周期,我们将继续提供有关阿尔茨海默病(AD)和相关痴呆症的神经行为学,神经内分泌学和神经遗传学临床研究的博士后培训。特别是,该计划将侧重于培训能够将基础科学的关键发现转化为有关AD病因学,病理生理学和治疗的假设的临床研究人员。此外,临床研究人员将在神经内分泌学和神经遗传学两个研究领域接受专门培训,这有望增加我们对AD发病机制的理解,并开发新的治疗方法。这些领域在精神科医生、神经科医生或神经心理学家的研究生培训中通常不被强调。然而,最近的进展强调了遗传因素如淀粉样前体蛋白和早老素突变以及载脂蛋白e基因型的重要性。神经内分泌因素如脂质、胰岛素和糖代谢紊乱、炎症和糖皮质激素状态也可能在改变AD易感基因的作用中起重要作用,从而影响AD的神经心理学表达。临床研究人员能够桥接神经遗传学,神经心理学和神经内分泌学领域将需要解开和定义这些潜在的关键相互作用。该计划得到了华盛顿大学和退伍军人事务部普吉特海湾医疗保健系统丰富的互动研究环境的支持,在那里,大量的教师在AD的神经内分泌学和神经遗传学方面进行基础科学和临床研究。华盛顿大学的ADRC也将作为教师和学员的资源。虽然我们的机构长期致力于老龄化培训,但我们提出的计划在其跨学科性质方面是独一无二的,并专注于AD和相关疾病的临床转化研究。因此,它将为临床研究科学家的培训提供急需的方法,这些科学家的工作将解决这些复杂的疾病。 相关性:我们的计划培养能够将基础科学的发现转化为阿尔茨海默病和其他痴呆症的临床模型的研究人员,从而促进这些具有挑战性的疾病的新治疗方法的开发。特别是,该计划侧重于遗传和代谢因素(如糖尿病和压力)在增加痴呆症风险方面所起的相互作用。这些因素在我们的社会中非常普遍,更好地了解它们的作用可能会导致预防痴呆症或延迟其发作的新治疗方法和策略。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Thomas J Montine其他文献

Prostaglandin E2 receptor subtype 2 (EP2) regulates microglial activation and associated neurotoxicity induced by aggregated α-synuclein
  • DOI:
    10.1186/1742-2094-4-2
  • 发表时间:
    2007-01-04
  • 期刊:
  • 影响因子:
    10.100
  • 作者:
    Jinghua Jin;Feng-Shiun Shie;Jun Liu;Yan Wang;Jeanne Davis;Aimee M Schantz;Kathleen S Montine;Thomas J Montine;Jing Zhang
  • 通讯作者:
    Jing Zhang

Thomas J Montine的其他文献

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{{ truncateString('Thomas J Montine', 18)}}的其他基金

Neuropath Core
神经病核心
  • 批准号:
    10262851
  • 财政年份:
    2021
  • 资助金额:
    $ 38.78万
  • 项目类别:
Neuropath Core
神经病核心
  • 批准号:
    10663237
  • 财政年份:
    2021
  • 资助金额:
    $ 38.78万
  • 项目类别:
Neuropath Core
神经病核心
  • 批准号:
    10461184
  • 财政年份:
    2021
  • 资助金额:
    $ 38.78万
  • 项目类别:
Project 2: Particle and brain mapping of CSF proteins using elemental reporters with mass spectrometry
项目 2:使用元素报告仪和质谱法对 CSF 蛋白进行粒子和脑图谱分析
  • 批准号:
    10359193
  • 财政年份:
    2020
  • 资助金额:
    $ 38.78万
  • 项目类别:
Neuropathology Core
神经病理学核心
  • 批准号:
    10409745
  • 财政年份:
    2020
  • 资助金额:
    $ 38.78万
  • 项目类别:
Neuropathology Core
神经病理学核心
  • 批准号:
    10176345
  • 财政年份:
    2020
  • 资助金额:
    $ 38.78万
  • 项目类别:
Project 2: Particle and brain mapping of CSF proteins using elemental reporters with mass spectrometry
项目 2:使用元素报告仪和质谱法对 CSF 蛋白进行粒子和脑图谱分析
  • 批准号:
    10573262
  • 财政年份:
    2020
  • 资助金额:
    $ 38.78万
  • 项目类别:
Neuropathology Core
神经病理学核心
  • 批准号:
    10385833
  • 财政年份:
    2019
  • 资助金额:
    $ 38.78万
  • 项目类别:
Neuropathology Core
神经病理学核心
  • 批准号:
    10601059
  • 财政年份:
    2019
  • 资助金额:
    $ 38.78万
  • 项目类别:
Clinical Genome Resource (ClinGen)
临床基因组资源 (ClinGen)
  • 批准号:
    9769097
  • 财政年份:
    2017
  • 资助金额:
    $ 38.78万
  • 项目类别:

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