Optical imaging of turbid media for medical diagnostics

材料的非侵入性化学深度分析在广泛的应用中具有很高的兴趣。空间偏移拉曼光谱（Spatial offset Raman spectroscopy， SORS）是一种新兴的技术，用于测量扩散散射样品中的地下化学信息，通常在20um - 5mm范围内，这是其他光谱技术无法达到的。然而，这个深度范围在医学诊断中具有很高的兴趣。该项目的主要目标是开发基于传感器和超声调制的新型光学仪器和建模技术，用于皮肤的亚表面诊断。在组织工程中的应用也将被探讨，特别是对工程骨移植物生长的非侵入性监测。

Non-invasive chemical depth-profiling of materials is of high interest in a broad variety of applications. Spatial offset Raman spectroscopy (SORS) is an emerging technique for measuring the subsurface chemical information in diffusely scattering samples, typically from depths of 20 um - 5 mm range, which is beyond the reach of other spectroscopic techniques. However, this depth range is of high interest in medical diagnostics. The main objective of this project is to develop novel optical instrumentation and modelling techniques based on SORS and ultrasound modulation for sub-surface diagnosis of skin. Applications to tissue engineering will also be explored, in particular for non-invasive monitoring the growth of engineered bone grafts.