POISE: A NOVEL APPROACH FOR DETERMINING OPTICAL PROPERTIES OF TURBID MEDIA

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 POISe是一种用于成像和/或确定混浊样品的光学性质的技术，通过测量其在用短（<10 ns）激光脉冲照射后的表面位移。该技术是通过一个修改后的马赫-曾德尔干涉仪能够测量表面位移的轴向精度为0.5纳米，和时间分辨率为4纳秒。 吸收系数和约化散射系数由下式确定： 将POISe测量值拟合到描述 时间分辨的表面变形作为光学和 目标的热物理性质。 我们提出了仪器的能力和一些初步的 POISe系统的结果用于确定的光学性质， 两个均匀混浊的组织体模。我们表明，吸收和 由POISe估计的约化散射系数相对较好 与通过更成熟的方法得出的结果一致， 频域光子迁移（FDPM）。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. POISe is a technique for imaging and/or determining the optical properties of a turbid sample by measuring its surface displacement following irradiation with a short (<10 ns) laser pulse. The technique is enabled by a modified Mach-Zehnder interferometer capable of measuring surface displacements with an axial precision of 0.5 nm, and a temporal resolution of 4 ns. The absorption and reduced scattering coefficients are determined by fitting the POISe measurement to model functions that describe the time-resolved surface deformation as a function of optical and thermophysical properties of the target. We present the capabilities of the instrument and a few preliminary results of the POISe system used to determine the optical properties of two homogeneous, turbid tissue phantoms. We show that the absorption and reduced scattering coefficients estimated by POISe are in relatively good agreement with those derived through the more established method of frequency domain photon migration (FDPM).