POISE: A NOVEL APPROACH FOR DETERMINING OPTICAL PROPERTIES OF TURBID MEDIA

Poise：一种确定浑浊介质光学特性的新方法

• 批准号: 8362621
• 负责人: VASAN VENUGOPALAN
• 金额: $ 2.93万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362621
• 关键词: Agreement; Biotechnology; Frequencies; Funding; Grant; Imaging Techniques; Lasers; Measurement; Measures; Methods; Modeling; National Center for Research Resources; Optics; Photons; Physiologic pulse; Principal Investigator; Property; Research; Research Infrastructure; Resolution; Resources; Sampling; Source; Surface; System; Techniques; Time; United States National Institutes of Health; absorption; cost; instrument; irradiation; migration; novel strategies; tissue phantom

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. POISe is a technique for imaging and/or determining the optical properties of a turbid sample by measuring its surface displacement following irradiation with a short (<10 ns) laser pulse. The technique is enabled by a modified Mach-Zehnder interferometer capable of measuring surface displacements with an axial precision of 0.5 nm, and a temporal resolution of 4 ns. The absorption and reduced scattering coefficients are determined by fitting the POISe measurement to model functions that describe the time-resolved surface deformation as a function of optical and thermophysical properties of the target. We present the capabilities of the instrument and a few preliminary results of the POISe system used to determine the optical properties of two homogeneous, turbid tissue phantoms. We show that the absorption and reduced scattering coefficients estimated by POISe are in relatively good agreement with those derived through the more established method of frequency domain photon migration (FDPM).

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 POISe 是一种通过测量短（<10 ns）激光脉冲照射后的表面位移来成像和/或确定混浊样品光学特性的技术。该技术通过改进的马赫-曾德干涉仪实现，能够以 0.5 nm 的轴向精度和 4 ns 的时间分辨率测量表面位移。 吸收和减少的散射系数由下式确定 将 POISe 测量值拟合到描述 时间分辨表面变形作为光学和 目标的热物理特性。 我们介绍该仪器的功能和一些初步的 POISe 系统的结果用于确定光学特性 两个均匀的、浑浊的组织模型。我们表明吸收和 POISe 估计的减少散射系数相对较好 与通过更成熟的方法得出的一致 频域光子迁移（FDPM）。