POISE: A NOVEL APPROACH FOR DETERMINING OPTICAL PROPERTIES OF TURBID MEDIA

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 Poise是一种用于成像和/或确定混浊样品的光学性质的技术，方法是在短(&lt；10 ns)激光脉冲照射后测量其表面位移。这项技术是由改进的马赫-曾德尔干涉仪实现的，该干涉仪能够测量表面位移，轴向精度为0.5 nm，时间分辨率为4 ns。 吸收系数和折合散射系数由下式确定 将平衡度测量拟合到描述 时间分辨表面变形作为光学和光学的函数 目标的热物理性质。 我们介绍了该仪器的功能和几个初步的 用于确定光学特性的泊松系统的结果 两个均匀混浊的组织幻影。我们证明了吸收和 由POISE估计的折合散射系数相对较好 与通过更成熟的方法得出的结果一致 频域光子迁移(FDPM)。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. POISe is a technique for imaging and/or determining the optical properties of a turbid sample by measuring its surface displacement following irradiation with a short (<10 ns) laser pulse. The technique is enabled by a modified Mach-Zehnder interferometer capable of measuring surface displacements with an axial precision of 0.5 nm, and a temporal resolution of 4 ns. The absorption and reduced scattering coefficients are determined by fitting the POISe measurement to model functions that describe the time-resolved surface deformation as a function of optical and thermophysical properties of the target. We present the capabilities of the instrument and a few preliminary results of the POISe system used to determine the optical properties of two homogeneous, turbid tissue phantoms. We show that the absorption and reduced scattering coefficients estimated by POISe are in relatively good agreement with those derived through the more established method of frequency domain photon migration (FDPM).