POISE: A NOVEL APPROACH FOR DETERMINING OPTICAL PROPERTIES OF TURBID MEDIA

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 Poise是一种用于成像和/或确定混浊样品的光学性质的技术，方法是在短(&lt；10 ns)激光脉冲照射后测量其表面位移。这项技术是由改进的马赫-曾德尔干涉仪实现的，该干涉仪能够测量表面位移，轴向精度为0.5 nm，时间分辨率为4 ns。 吸收系数和折合散射系数由下式确定 将平衡度测量拟合到描述 时间分辨表面变形作为光学和光学的函数 目标的热物理性质。 我们介绍了该仪器的功能和几个初步的 用于确定光学特性的泊松系统的结果 两个均匀混浊的组织幻影。我们证明了吸收和 由POISE估计的折合散射系数相对较好 与通过更成熟的方法得出的结果一致 频域光子迁移(FDPM)。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. POISe is a technique for imaging and/or determining the optical properties of a turbid sample by measuring its surface displacement following irradiation with a short (<10 ns) laser pulse. The technique is enabled by a modified Mach-Zehnder interferometer capable of measuring surface displacements with an axial precision of 0.5 nm, and a temporal resolution of 4 ns. The absorption and reduced scattering coefficients are determined by fitting the POISe measurement to model functions that describe the time-resolved surface deformation as a function of optical and thermophysical properties of the target. We present the capabilities of the instrument and a few preliminary results of the POISe system used to determine the optical properties of two homogeneous, turbid tissue phantoms. We show that the absorption and reduced scattering coefficients estimated by POISe are in relatively good agreement with those derived through the more established method of frequency domain photon migration (FDPM).