Symptom Management in Blood and Marrow Transplantation

描述：（由申请人提供）本申请寻求支持 研究的目的是调查如何非洲裔美国人，拉丁美洲人， 患有BMT的非少数民族患者的症状和生活质量（QOL） 在移植后的前100天内增加了8倍。包括 足够数量的非洲裔美国人和拉丁美洲患者是一个重要的重点 因为几乎没有BMT研究包括种族 足够数量的少数患者，以记录其 症状和生活质量。来自其他人群的证据表明， 症状会因种族而异。这种治疗的成功、生存， 患者的生活质量与骨髓移植症状有关。患者 在一些研究中，他们对生活质量的评价是积极的，尽管 经历心理和身体后遗症，如疲劳、焦虑、疼痛， 性功能障碍，抑郁，睡眠障碍，无法恢复 工作，害怕复发或死亡。重要的是要区分 症状患病率和感知QOL。生活质量仍然有各种各样的 各种定义和衡量标准。因此，该项目将 使用三角形设计，包括重复测量两个定量 和现象学数据。该项目将确定生活质量和患病率 和症状的严重程度，并包括这些系统的专题分析 人的经验。这些经验的组成部分将进行比较 纵向与症状患病率和严重程度以及QOL（通过 标准仪器。这些数据在文献中是缺乏的， 有几个原因症状是严重的，已知随着时间的推移和 不同的种族群体，患者的生存率和BMT后的QOL取决于 有效的症状管理。患者对自己的意义的看法 经验有助于创造他们的需求，以及如何最好地满足这些需求。 met.这些数据对于更全面地理解生活质量的意义至关重要， 这些人，以帮助解释令人困惑的发现， 尽管经历了许多症状，但他们的QOL仍然很高， 有效和文化上适当的干预措施。未来的研究将集中 制定和测试适当的干预措施。

DESCRIPTION: (provided by applicant) This application seeks support for research with the aim of investigating how African American, Latino, and non-minority persons who have BMT experience symptoms and quality of life (QOL) at eight times over the first 100 days after their transplantation. Including African American and Latino patients in sufficient number is an important focus for this research because virtually no BMT research has included ethnic minority patients in sufficient numbers to document differences in their symptoms and quality of life. Evidence from other populations indicates that symptoms will differ by ethnic group. The success of this treatment, survival, and the quality of life for patients are related to the BMT symptoms. Patients in several studies have rated their quality of life positively, despite experiencing psychosocial and physical sequelae such as fatigue, anxiety, pain, sexual dysfunction, depression, sleep disturbances, inability to return to work, and fear of relapse or death. It is important to distinguish between symptom prevalence and perceived QOL. QOL continues to have a variety of definitions a variety of definitions and measures. Therefore, this project will use a triangulated design that includes repeated measures of both quantitative and phenomenological data. The project will determine the QOL and prevalence and severity of symptoms and include a systematic thematic analysis of these persons' experiences. The components of these experiences will be compared longitudinally with symptom prevalence and severity and QOL as measured by standard instruments. These data are lacking in the literature and are needed for several reasons. Symptoms are severe, known to vary over time and for different ethnic groups, and patient survival and QOL post-BMT depend on effective symptom management. The meanings patients attribute to their experiences help create the needs they have and how these needs can best be met. These data are crucial to more fully understand the meaning of QOL for these persons, to help explain the puzzling finding that persons who have BMT rate their QOL high despite experiencing many symptoms, and to develop effective and culturally appropriate interventions. Future research will focus on developing and testing appropriate interventions.