Symptom Management in Blood and Marrow Transplantation

血液和骨髓移植中的症状管理

• 批准号: 6621530
• 负责人: MARLENE ZICHI COHEN
• 金额: $ 33.84万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-03-01 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6621530
• 关键词: African American; Hispanic Americans; bone marrow transplantation; caucasian American; functional ability; human subject; patient care management; patient oriented research; postoperative state; quality of life; racial /ethnic difference; sign /symptom

DESCRIPTION: (provided by applicant) This application seeks support for research with the aim of investigating how African American, Latino, and non-minority persons who have BMT experience symptoms and quality of life (QOL) at eight times over the first 100 days after their transplantation. Including African American and Latino patients in sufficient number is an important focus for this research because virtually no BMT research has included ethnic minority patients in sufficient numbers to document differences in their symptoms and quality of life. Evidence from other populations indicates that symptoms will differ by ethnic group. The success of this treatment, survival, and the quality of life for patients are related to the BMT symptoms. Patients in several studies have rated their quality of life positively, despite experiencing psychosocial and physical sequelae such as fatigue, anxiety, pain, sexual dysfunction, depression, sleep disturbances, inability to return to work, and fear of relapse or death. It is important to distinguish between symptom prevalence and perceived QOL. QOL continues to have a variety of definitions a variety of definitions and measures. Therefore, this project will use a triangulated design that includes repeated measures of both quantitative and phenomenological data. The project will determine the QOL and prevalence and severity of symptoms and include a systematic thematic analysis of these persons' experiences. The components of these experiences will be compared longitudinally with symptom prevalence and severity and QOL as measured by standard instruments. These data are lacking in the literature and are needed for several reasons. Symptoms are severe, known to vary over time and for different ethnic groups, and patient survival and QOL post-BMT depend on effective symptom management. The meanings patients attribute to their experiences help create the needs they have and how these needs can best be met. These data are crucial to more fully understand the meaning of QOL for these persons, to help explain the puzzling finding that persons who have BMT rate their QOL high despite experiencing many symptoms, and to develop effective and culturally appropriate interventions. Future research will focus on developing and testing appropriate interventions.

描述：(申请人提供)本申请寻求支持 研究的目的是调查非裔美国人、拉丁裔和 患有骨髓移植的非少数民族患者的症状和生活质量(QOL) 在他们移植后的前100天里有8次。包括 足够数量的非洲裔和拉丁裔患者是一个重要的关注点 因为几乎没有任何BMT研究包括种族 有足够数量的少数族裔患者记录他们的差异 症状和生活质量。来自其他人群的证据表明 不同民族的症状会有所不同。这种治疗的成功，存活， 患者的生活质量与骨髓移植的症状密切相关。病人 在几项研究中对他们的生活质量给予了积极的评价，尽管 经历心理社会和身体上的后遗症，如疲劳、焦虑、疼痛、 性功能障碍，抑郁，睡眠障碍，无法回到 工作，以及对复发或死亡的恐惧。重要的是要区分 症状患病率和感知生活质量。QOL继续拥有各种各样的 定义有多种定义和衡量标准。因此，这个项目将 使用三角设计，其中包括两个数量的重复测量 和现象学数据。该项目将决定患者的生活质量和患病率 和症状的严重性，并包括对这些的系统主题分析 人的经历。这些体验的组成部分将进行比较 纵向与症状发生率、严重程度和生活质量进行比较 标准乐器。这些数据在文献中是缺乏的，需要的 有几个原因。症状很严重，已知会随着时间的推移而变化 不同的种族，患者的存活率和骨髓移植后的生活质量取决于 有效的症状管理。患者赋予他们的意义 体验有助于创建他们拥有的需求，以及如何最好地满足这些需求 相遇了。这些数据对于更充分地理解生活质量对于 这些人，以帮助解释令人费解的发现，患有骨髓移植的人 尽管经历了许多症状，但他们的生活质量仍然很高，并 有效和文化上适当的干预措施。未来的研究将集中在 关于制定和测试适当的干预措施。