PET STUDY OF CNS BENZODIAZEPINE RECEPTORS IN ADOLESCENT ONSET ALCOHOLISM

青少年酒精中毒中枢神经系统苯二氮卓受体的 PET 研究

• 批准号: 6304692
• 负责人: DUNCAN B. CLARK
• 金额: $ 0.3万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6304692
• 关键词: adolescence (12-20); alcoholic beverage consumption; alcoholism /alcohol abuse; benzodiazepine receptor; central nervous system disorders; clinical research; human subject; neurochemistry; positron emission tomography; receptor expression; receptor sensitivity; toxicant interaction; toxicology

This study proposes to obtain pilot data on the effects of chronic and alcohol consumption on benzodiazepine receptor (BZR) distribution and density in adolescent onset alcohol dependence using [11C] flumazenil binding visualized by PET. Alterations in the gamma-aminobutyric acid (GABA) neurotransmitter system induced by chronic alcohol consumption represent the mostly likely neurochemical substrate of alcohol dependence. Subjects with adolescent-onset alcohol use disorders, compared with controls, will show reduced binding of [11C]-flumazenil in the cingulate cortex.

本研究旨在通过PET显像观察[11 C]氟马西尼结合，获得慢性饮酒和饮酒对青少年酒精依赖患者苯二氮卓类受体（BZR）分布和密度影响的初步数据。 长期饮酒引起的γ-氨基丁酸（GABA）神经递质系统的改变是酒精依赖最可能的神经化学底物。与对照组相比，酒精使用障碍患者的扣带回皮质中[11 C]-氟马西尼结合减少。