New Synthetic Approaches to Halogenated Medium Ring Ethers from Laurencia

自20世纪60年代分离Laurencin以来，Laurencia物种的卤代中环醚吸引了许多合成关注。1，2我们最近提出并实验证实了这些结构复杂分子的统一生物起源。3，4在这项工作中，我们采用了一种新的分子内环化方案。我们现在打算将这项工作扩展到更灵活的分子间功能化方法。通过这种方式，我们将针对天然存在的氯溴化物中环醚的家庭。该项目符合至少两个EPSRC的优先领域：催化和新颖高效的化学合成。1. Irie，T.; Suzuki，M.; Masamune，T. Tetrahedron Lett. 1965，16，1091-1099. 2.有关综述，请参见：Wang，B.- G.地; Gloer，J. B.; Ji，N.- Y的; Zhao，J.- C. 2013，113，3632-36853中所述。Bonney，K. J.道：Braddock，D. C. 2012，77，9574-9584和其中引用的参考文献。最近的工作针对双环成员的类见：布洛克，D。C.的; Sbircea，D. T.化学通信2014，50，12691-12693.4.关于该方法的发展，参见：Bonney，K. J.道：Braddock，D. C.的;白色，A. J. P.; Yaqoob，M. J. Org. Chem. 2011，76，97-104。

The halogenated medium ring ethers from Laurencia species have attracted much synthetic attention since the isolation of Laurencin in the 1960s.1,2 We have recently proposed and experimental corroborated a unifying biogenesis of these structurally complex molecules.3,4 In that work we employed a novel intramolecular cyclisation protocol. We now intend to extend this work to a more flexible intermolecular functionalization method. In this manner we will target the naturally occurring chlorobromide medium ring ethers of the family.The project fits with at least two EPSRC priority areas: Catalysis & Novel and Efficient Chemical Synthesis.1. Irie, T.; Suzuki, M.; Masamune, T. Tetrahedron Lett. 1965, 16, 1091-1099. 2. For a review see: Wang, B.-G.; Gloer, J. B.; Ji, N.-Y.; Zhao, J.-C. Chem. Rev. 2013, 113, 3632-36853. Bonney, K. J.; Braddock, D. C. J. Org. Chem. 2012, 77, 9574-9584 and references cited therein. For more recent work targeting bicyclic members of the class see: Braddock, D. C.; Sbircea, D.-T. Chem. Commun. 2014, 50, 12691-12693.4. For the development of the method see: Bonney, K. J.; Braddock, D. C.; White, A. J. P.; Yaqoob, M. J. Org. Chem. 2011, 76, 97-104.