New synthetic approaches to fluoroorganic compounds

含氟有机化合物的新合成方法

• 批准号: 326959-2007
• 负责人: Paquin, JeanFrançois
• 金额: $ 2.77万
• 依托单位: Université Laval
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2009
• 资助国家: 加拿大
• 起止时间: 2009-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=428584
• 关键词: New; synthetic; approaches; fluoroorganic; compounds

The presence of a fluorine atom often modifies the activity of a bioactive molecule by changing its solubility, lipophilicity, metabolic stability, conformation, hydrogen bonding ability, or chemical reactivity. In fact, as many as 30-40% of agrochemicals and 20% of pharmaceuticals on the market are estimated to contain fluorine, including half of the top 10 drugs sold in 2005. As a result, the demand for more practical, selective, and efficient methodologies for the synthesis of fluorinated molecules is increasing.

氟原子的存在通常通过改变其溶解性、亲脂性、代谢稳定性、构象、氢键能力或化学反应性来改变生物活性分子的活性。事实上，据估计，市场上多达30%-40%的农用化学品和20%的药品含有氟，其中包括2005年销售的前十大药品中的一半。因此，对合成氟化分子的更实用、更有选择性和更有效的方法的需求正在增加。