COCAINE EXPOSURE IN UTERO--ELEMENTARY SHCOOL FOLLOWUP

宫内可卡因暴露对儿童认知和社交的影响 学龄前和小学的能力是一个重大公共政策问题 担心..这种早期的竞争性更新将继续纵向进行 对一个独特的、以非裔美国人为主的完整任期的前瞻性评估 已经有大约200名低收入的照看孩子的夫妻 从出生到2岁的研究。为了解决剂量效应问题，母亲 孕妇尿液和新生儿胎粪的访谈和放射免疫分析 用于将该样本归类为未暴露、轻微或。沉重地 暴露在可卡因中。三项评估将最大限度地减少答辩人的负担 描述没有基效应的多个区域。48个月 使用WPSSI-R和On评估认知能力 使用计算机化的持续执行任务来保持注意力。这个 Goodman Lock Box和照顾者解决儿童问题的任务将评估 基本的行政职能，包括规划、自我调节和 影响调制。60个月时的小学语言发展测试 皮博迪发展运动技能将提供详细的评估 语言和运动领域。72个月的就学准备和学习 残障人士将通过WIAT和WRAML进行测试。社交和 可能改变或加剧可卡因影响的环境因素将 记录有学龄前家庭评估和年度照顾者 采访。覆盖儿童的行为问题(CBCL) ，健康，教育经历，照顾者的变化，以及接触 暴力和他们自己的酒精和非法药物使用，压力，抑郁， 和社会支持。多变量分析，包括通径分析和 聚类技术，将被用来评估是否存在独立的 宫内可卡因暴露对儿童风险的剂量反应效应 认知功能障碍和社交功能障碍。这些数据将为公共政策提供信息 对接触可卡因的学龄前和小学儿童的护理选择 全国范围内。

Whether in utero cocaine exposure effects children's cognitive and social competence in pre and primary school is a question of major public policy concern.. This early competing renewal will continue longitudinal prospective evaluation of a unique predominantly African-American full term cohort of approximately 200 low income caretaker-child dyads already studied from birth to age 2. To address issues of dose effects,maternal interviews and radioimmunoassays of maternal urine and neonatal meconium were used to categorize this sample as unexposed, lightly, or. heavily exposed to cocaine. Three assessments will minimize respondent burden and characterize multiple domains without basement effect. The 48 month assessment focusses on cognitive competence using the WPSSI-R and on sustained attention using a computerized continuance performance task. The Goodman Lock Box and a care giver child problem solving task will assess rudimentary executive functions including planning, self regulation and affect modulation. At 60 months the Test of Language Development Primary and the Peabody Developmental Motor Skills will provide detailed assessment of language and motor domains. At 72 months school readiness and learning disabilities will be tested with the WIAT and the WRAML. Social and environmental factors which may modify or exacerbate cocaine effects will be documented with a preschool HOME assessment and yearly caretaker interviews . covering the child's behavior problems (CBCL) ,health,educational experience,changes in caretakers, and exposure to violence and their own alcohol and illicit drug use, stress, depression, and social support. Multiple variable analysis, including path analysis and clustering techniques, will be used to assess whether there are independent dose response effects of in utero cocaine exposure upon the child's risk for cognitive and social dysfunction. These data will inform public Policy choices for the care of cocaine exposed pre and primary school children nationwide.