COCAINE EXPOSURE IN UTERO--ELEMENTARY SHCOOL FOLLOWUP

子宫内可卡因接触——小学随访

• 批准号: 6649877
• 负责人: Deborah A Frank
• 金额: $ 102.19万
• 依托单位: BOSTON MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-08-01 至 2004-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6649877
• 关键词: African American; academic achievement; caregivers; child behavior disorders; child psychology; cocaine; cognition disorders; developmental psychology; elementary school; embryo /fetus toxicology; emotional adjustment; functional ability; human subject; longitudinal human study; low socioeconomic status; middle childhood (6-11); neuropsychological tests; parents; postnatal growth disorder; prenatal growth disorder; preschool child (1-5); psychomotor disorders; social adjustment; social support network

Whether in utero cocaine exposure effects children's cognitive and social competence in pre and primary school is a question of major public policy concern.. This early competing renewal will continue longitudinal prospective evaluation of a unique predominantly African-American full term cohort of approximately 200 low income caretaker-child dyads already studied from birth to age 2. To address issues of dose effects,maternal interviews and radioimmunoassays of maternal urine and neonatal meconium were used to categorize this sample as unexposed, lightly, or. heavily exposed to cocaine. Three assessments will minimize respondent burden and characterize multiple domains without basement effect. The 48 month assessment focusses on cognitive competence using the WPSSI-R and on sustained attention using a computerized continuance performance task. The Goodman Lock Box and a care giver child problem solving task will assess rudimentary executive functions including planning, self regulation and affect modulation. At 60 months the Test of Language Development Primary and the Peabody Developmental Motor Skills will provide detailed assessment of language and motor domains. At 72 months school readiness and learning disabilities will be tested with the WIAT and the WRAML. Social and environmental factors which may modify or exacerbate cocaine effects will be documented with a preschool HOME assessment and yearly caretaker interviews . covering the child's behavior problems (CBCL) ,health,educational experience,changes in caretakers, and exposure to violence and their own alcohol and illicit drug use, stress, depression, and social support. Multiple variable analysis, including path analysis and clustering techniques, will be used to assess whether there are independent dose response effects of in utero cocaine exposure upon the child's risk for cognitive and social dysfunction. These data will inform public Policy choices for the care of cocaine exposed pre and primary school children nationwide.

子宫内可卡因暴露是否影响儿童的认知和社交能力 学前教育和小学的能力是一个重大的公共政策问题 关注..这种早期的竞争更新将继续纵向 对一个独特的主要是非洲裔美国人的完整任期的前瞻性评价 大约200名低收入家庭的照顾者和儿童的组合已经 从出生到2岁。 为了解决剂量效应问题， 母亲尿液和新生儿胎粪的面谈和放射免疫测定 被用来将这个样本分类为未暴露的，轻度的，或。严重 接触可卡因三项评估将最大限度地减少答卷人的负担， 表征多个域而无基底效应。 48个月 评估的重点是使用WPSSI-R的认知能力， 持续的注意力，使用计算机化的持续性能任务。的 嘉民锁箱和一个照顾者解决儿童问题的任务将评估 基本的执行功能，包括规划、自我调节和 影响调制。在60个月的语言发展测试小学 皮博迪运动技能发展中心将提供详细的评估 语言和运动领域的联系。72个月入学准备和学习 将使用WIAT和WRAML进行残疾测试。社会和 可能改变或加剧可卡因效应的环境因素将 记录学前家庭评估和年度看护人 采访儿童行为问题（CBCL） 、健康、教育经历、照顾者的变化以及接触 暴力和他们自己的酒精和非法药物的使用，压力，抑郁， 和社会支持。多变量分析，包括路径分析和 聚类技术，将用于评估是否有独立的 子宫内可卡因暴露对儿童风险的剂量反应效应 认知和社交功能障碍这些数据将为公共政策提供信息 接触可卡因的学龄前和小学儿童的护理选择 全国范围