PRIMARY CARE ENRICHMENT PROTOCOL (PEP)

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 在子宫内接触可卡因是否会影响儿童的学习能力和在家庭和学校的行为是一个主要的公共政策问题。由于数据很少，人们强烈声称这些儿童患有严重残疾，无法正常学习和行为。然而，大多数这些主张忽视了儿童环境在决定结果方面的重要性。该项目的目标是收集关于子宫内接触可卡因的儿童的真实的问题的可信科学数据。目前，这项纵向赠款正在评估子宫内可卡因暴露对从出生到10.5岁足月出生的儿童的潜在多方面影响。当前补助金的延长旨在跟踪同一组儿童的青春期（12-18岁）。 该项目有两个主要目标。 1.评估在静态控制潜在混杂的生物和社会变量后，子宫内可卡因暴露水平（无、轻、重）与选定的发育和社会情感结果之间是否存在独立关系，这些结果仅在童年中期清楚地出现。 2.利用这一纵向数据集来识别历史和并发的生物和社会因素，这些因素与可卡因暴露水平相互作用，区分青少年时期在神经心理，情感和行为领域表现出不良后果的儿童和未表现出不良后果的儿童。青少年接触可卡因的儿童的初步数据很少。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Whether exposure to cocaine in the womb affects children s learning abilities and behavior in family and school is a question of major public policy concern. With very little data, drastic claims have been made that these children are irrevocably disabled and incapable of normal learning and behavior. However, most of these claims ignore the importance of a child's environment in determining outcome. The goal of this project is to gather credible scientific data regarding what are and are not the real problems of children exposed to cocaine in the womb. Currently, this longitudinal grant is assessing the potential multidimensional effects of in utero cocaine exposure upon children born at term from birth to 10.5 years. This extension of the current grant intends to follow the same group of children through adolescence (12-18 years). This project has two major goals. 1.To evaluate whether, after potentially confounding biologic and social variables are controlled statically, there are independent relationships between level of in utero cocaine exposure (none, light, heavy) and selected developmental and socio-affective outcomes which are only clearly emerging in middle childhood. 2.To use this longitudinal data set to identify historical and concurrent biologic and social factors, which in interaction with level of cocaine exposure, differentiate children who do and do not show adverse outcomes in neuropsychological, emotional and behavioral domains in adolescent years. Little preliminary data is available for cocaine exposed children in adolescence.