CLINICAL & SEROLOGIC PREDICTORS OF NEUROPSYCHIATRIC SLE

据估计，高达75%的系统性红斑狼疮（SLE）患者在其病程的某个时间点经历某种类型的神经系统表现。 最常见的包括中风、认知功能障碍和精神疾病，尽管尚未对其全部范围进行表征。 这项为期五年的SLE患者神经系统疾病前瞻性研究的目的是描述不同种族但主要是墨西哥裔美国人的SLE患者神经系统受累谱，并定义可能是特定靶向神经系统表现的独特重要风险因素。 该研究的假设之一是，在aPL和抗apoH抗体持续异常水平的SLE患者中，血栓闭塞事件的风险将更高，并且认知功能障碍的发展将与这些抗体的异常血清水平暂时相关。

It has been estimated that up to 75% of patients with Systemic Lupus Erythematosus (SLE) experience some type of nervous system manifestations at some point in their disease course. The most common include stroke, cognitive dysfunction and psychiatric disease, although the full range has not been characterized. This five year, prospective study of nervous system disease in SLE patients has as its objectives the characterization of the spectrum of nervous system involvement in an ethnically diverse but predominately Mexican-American population of patients with SLE and the definition of important risk factors which may be unique for specifically targeted nervous system manifestations. Among the study's hypotheses is that the risk of thrombo-occlusive events will be higher in SLE patients who have persistently abnormal levels of aPL and anti-apoH antibodies and that the development of cognitive dysfunction will be temporally associated with abnormal serum levels of these antibodies.