4.7 T Small Aninal MR Imaging and Spectroscopy System

描述(申请人提供)：我们要求一台4.7T水平口径小动物多核磁共振成像和光谱分析系统，以下称为小动物MRVS系统，用于活体细胞和分子成像。该系统将是我们创建一个多机构、俄亥俄州细胞和分子成像联盟(OCMIC)计划的组成部分。这项开发具有多种成像资源的小动物成像的计划建立在遗传学和小动物疾病模型、癌症生物学和神经科学以及成像技术的现有专业知识的基础上。OCMIC将利用从这项提案和各种相关提案获得的资金来开发。所要求的小动物-MRVS系统的成功利用是由于许多致力于该系统使用的教师和凯斯西部储备大学(CWRU)现有的两个开发奖项。第一项是惠特克发展奖的延期，其中包括三名新的小动物成像教员，其中包括一名MR造影剂的新人。这些新的教员将补充现有的成像教员，他们拥有磁共振成像、图像分析和造影剂设计方面的技能。第二个是NIH资助的P20规划拨款，用于创建体内细胞和分子成像中心(Pre-ICMIC)。CWRU医学院、工程学院和艺术与科学学院提供了广泛的跨学科支持。在北俄亥俄州没有现有的活体显微核磁共振系统，我们打算通过OCMIC将该系统提供给许多致力于此的研究人员。克利夫兰大学医院、凯斯西储大学、克利夫兰临床基金会和克利夫兰州立大学已经确定了潜在用户。已确定了许多PI，并在癌症、神经科学、组织工程和心血管研究领域进行了样本研究项目。该项目的合理管理计划建立在我们对癌症中心核心设施的经验基础上，该核心设施包括一个双光子共聚焦显微镜和一个垂直钻孔7.0T核磁共振系统，该系统将进行升级，以适合切除组织的成像。OCMIC和前ICMIC将为扩大用户基础提供一个框架，以包括大量现有的NIH资助的研究人员。有了758,500美元的机构现金承诺，再加上非现金承诺和与该项目有关的其他建议，我们有一个健全的成功财务计划。

DESCRIPTION (provided by applicant): We request a 4.7T horizontal bore small animal multinuclear MR imaging and spectroscopy system, hereafter referred to as the small animal MRVS system, for in vivo cellular and molecular imaging. This system will be an integral part of our plan to create a multi-institutional, Ohio Cellular and Molecular Imaging Consortium (OCMIC). This plan to develop small animal imaging with multiple imaging resources builds on existing expertise in genetics and small animal models of disease, cancer biology, and neuroscience, as well as imaging technology. The OCMIC will be developed using funds from this and various related proposals. The successful utilization of the requested small animal-MRVS system is made possible by many faculty dedicated to its use and by two existing development awards to Case Western Reserve University (CWRU). The first is a Whitaker Development Award extension that includes three new faculty members in small animal imaging, including a new person in MR contrast agents. These new faculty members will supplement existing faculty members in imaging who have skills in MR imaging, image analysis, and contrast agent design. The second is an NIH funded P20 planning grant to create an In Vivo Cellular and Molecular lmaging Center (pre-ICMIC). There is wide interdisciplinary support from the CWRU Schools of Medicine, Engineering, and Arts and Sciences. There is no existing in vivo microscopic MRI system in all of Northern Ohio and we intend to make this system available to many committed researchers through the OCMIC. Potential users have been identified at University Hospitals of Cleveland, Case Western Reserve University, Cleveland Clinic Foundation, and Cleveland State University. Numerous PIs have been identified and sample research projects are in the areas of cancer, neuroscience, tissue engineering, and cardiovascular research. A rational plan for administration of the project builds on our experience with a Cancer Center Core facility consisting of a dual photon confocal microscope and a vertical bore 7.0T NMR system that will be upgraded to be suitable for imaging of excised tissue. The OCMIC and pre-ICMIC will provide a framework for growing the user base to include a large number of existing NIH funded researchers. With institutional cash commitments of $758,500, in addition to non-cash commitments and other proposals related to this project, we have a sound financial plan for success.