4.7 T Small Aninal MR Imaging and Spectroscopy System

4.7T小型动物磁共振成像及光谱系统

• 批准号: 6501291
• 负责人: JONATHAN S LEWIN
• 金额: $ 132.5万
• 依托单位: UNIVERSITY HOSPITALS OF CLEVELAND
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-23 至 2006-09-22
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6501291
• 关键词: Rodentias; biomedical equipment purchase; magnetic resonance imaging; spectrometry

DESCRIPTION (provided by applicant): We request a 4.7T horizontal bore small animal multinuclear MR imaging and spectroscopy system, hereafter referred to as the small animal MRVS system, for in vivo cellular and molecular imaging. This system will be an integral part of our plan to create a multi-institutional, Ohio Cellular and Molecular Imaging Consortium (OCMIC). This plan to develop small animal imaging with multiple imaging resources builds on existing expertise in genetics and small animal models of disease, cancer biology, and neuroscience, as well as imaging technology. The OCMIC will be developed using funds from this and various related proposals. The successful utilization of the requested small animal-MRVS system is made possible by many faculty dedicated to its use and by two existing development awards to Case Western Reserve University (CWRU). The first is a Whitaker Development Award extension that includes three new faculty members in small animal imaging, including a new person in MR contrast agents. These new faculty members will supplement existing faculty members in imaging who have skills in MR imaging, image analysis, and contrast agent design. The second is an NIH funded P20 planning grant to create an In Vivo Cellular and Molecular lmaging Center (pre-ICMIC). There is wide interdisciplinary support from the CWRU Schools of Medicine, Engineering, and Arts and Sciences. There is no existing in vivo microscopic MRI system in all of Northern Ohio and we intend to make this system available to many committed researchers through the OCMIC. Potential users have been identified at University Hospitals of Cleveland, Case Western Reserve University, Cleveland Clinic Foundation, and Cleveland State University. Numerous PIs have been identified and sample research projects are in the areas of cancer, neuroscience, tissue engineering, and cardiovascular research. A rational plan for administration of the project builds on our experience with a Cancer Center Core facility consisting of a dual photon confocal microscope and a vertical bore 7.0T NMR system that will be upgraded to be suitable for imaging of excised tissue. The OCMIC and pre-ICMIC will provide a framework for growing the user base to include a large number of existing NIH funded researchers. With institutional cash commitments of $758,500, in addition to non-cash commitments and other proposals related to this project, we have a sound financial plan for success.

描述（由申请人提供）：我们要求一个4.7T水平孔径小动物多核磁共振成像和光谱系统，以下简称小动物MRVS系统，用于体内细胞和分子成像。这个系统将是我们计划创建一个多机构的俄亥俄细胞和分子成像联盟（OCMIC）的一个组成部分。该计划以现有的遗传学和疾病小动物模型、癌症生物学、神经科学以及成像技术方面的专业知识为基础，利用多种成像资源开发小动物成像。OCMIC将利用这一建议和各种相关建议的资金来发展。小动物- mrvs系统的成功使用是由许多致力于使用该系统的教师和凯斯西储大学（CWRU）现有的两项开发奖励所实现的。首先是惠特克发展奖的扩展，包括小动物成像领域的三名新教员，包括MR造影剂领域的一名新教员。这些新教员将补充现有的具有磁共振成像、图像分析和造影剂设计技能的成像教员。第二个是NIH资助的P20计划拨款，用于创建一个体内细胞和分子成像中心（pre-ICMIC）。CWRU医学院、工程学院、艺术与科学学院为其提供了广泛的跨学科支持。在整个北俄亥俄州还没有现存的活体显微MRI系统，我们打算通过OCMIC将该系统提供给许多有承诺的研究人员。克利夫兰大学医院、凯斯西储大学、克利夫兰诊所基金会和克利夫兰州立大学已经确定了潜在的用户。在癌症、神经科学、组织工程和心血管研究领域，已经确定了许多pi和样本研究项目。合理的项目管理计划建立在我们对癌症中心核心设施的经验基础上，该设施包括双光子共聚焦显微镜和垂直孔径7.0T核磁共振系统，该系统将升级为适用于切除组织的成像。OCMIC和pre-ICMIC将提供一个框架，以扩大用户基础，包括大量现有的NIH资助的研究人员。机构现金承诺为758500美元，此外还有非现金承诺和与该项目有关的其他建议，我们有一个成功的健全财务计划。