Emory National Primate Research Center

总体--摘要/摘要 本申请寻求对P51基本补助金(OD 011132)的五年持续支持，用于 埃默里大学耶克斯国家灵长类动物研究中心。叶尔克家族的首要目标 中心将开展研究项目，重点研究与人类健康和美国国立卫生研究院有关的科学问题 通过在适当的科学和兽医专业方面提供资源基础设施和专门知识 并确保该中心有能力作为核心和附属科学家以及其他 来自区域、国家和国际的科学家。在本报告所述期间(2016年5月1日至今)， 耶克斯中心记录了显著的进展，如许多(&gt；550)出版物所证明的那样， 建造新的动物设施，并继续提供强劲的研究资金。此外，耶尔克斯灵长类动物 中心拥有出色的核心研究计划，并为广泛的 整个区域和国家的附属和协作调查人员的多学科网络。这些 涉及使用各种非人类灵长类物种的研究计划主要是针对 四个主要研究学科，代表耶克斯中心内的研究部门：1) 微生物学和免疫学；2)发育和认知神经科学；3)神经药理学和 神经疾病和行为神经科学和精神障碍。此外，通过分部 动物资源和病理学，耶克斯为外部调查人员在 Yerkes中心，与我们作为地区和国家资源的ORIP授权的角色一致。具体目标为 即将到来的支持期包括：1)使用非人类进行基础和翻译研究 灵长类扩大知识，开发改进的治疗方法，并推进造福人类的治疗方法；2) 提供区域和国家资源，提供数据、咨询专业知识、生物材料和专门知识 有助于支持非人灵长类研究的设施；3)研究基本的非人灵长类生物学和 改进非人类灵长类动物的繁殖、饲养和基因特征，以更好地服务于生物医学 研究社区；以及4)提供涉及非人类灵长类动物的研究和培训机会 研究生和本科生、博士后研究员、访问科学家和教职员工。这个 追求这些目标将增强中心作为核心和附属机构的有利资源的能力 科学家为了进行非人类灵长类动物的研究，都是为了促进人类健康和 人类和非人类灵长类的福祉。

OVERALL – SUMMARY/ABSTRACT This application seeks five years of continued support for the P51 Base Grant (OD 011132) for the operation of the Yerkes National Primate Research Center of Emory University. The overarching goals of the Yerkes Center are to conduct research programs focused on scientific problems relevant to human health and the NIH mission by providing resource infrastructure and expertise in appropriate scientific and veterinary specialties and to ensure the Center’s ability to serve as a resource to Core and Affiliated Scientists, as well as to other scientists regionally, nationally and internationally. During the current reporting period (5/1/2016 to present), the Yerkes Center has recorded remarkable progress, as evidenced by numerous (>550) publications, construction of new animal facilities, and continued robust research funding. In addition, the Yerkes Primate Center has maintained outstanding core research programs and provided resources and services to a broad multidisciplinary network of affiliate and collaborative investigators throughout the region and nation. These research programs, which involve the use of a variety of nonhuman primate species, are directed primarily toward four major research disciplines, representing the research divisions within the Yerkes Center: 1) Microbiology and Immunology; 2) Developmental and Cognitive Neuroscience, 3) Neuropharmacology and Neurologic Diseases and 4) Behavioral Neuroscience and Psychiatric Disorders. Also, through the Divisions of Animal Resources and Pathology, Yerkes provides support for outside investigators conducting research at the Yerkes Center, consistent with our ORIP-mandated role as a regional and national resource. Specific aims for the upcoming period of support include: 1) To carry out basic and translational research using nonhuman primates to expand knowledge, develop improved treatments, and advance cures that will benefit humanity; 2) To provide regional and national resources for data, consultative expertise, biologic materials, and specialized facilities useful in supporting nonhuman primate research; 3) To study basic nonhuman primate biology and improve nonhuman primate breeding, husbandry, and genetic characterization to better serve the biomedical research community; and 4) To provide research and training opportunities involving nonhuman primates to graduate and undergraduate students, postdoctoral fellows, visiting scientists, and faculty members. The pursuit of these aims will enhance the Center’s ability to serve as an enabling resource to Core and Affiliate Scientists for the conduct of nonhuman primate research, all for the ultimate goal of advancing the health and well-being of human and nonhuman primates.