PHybrid Quadrupole/Orthogonal Time-of-Flight Mass Spec

描述(由申请者提供)：购买混合动力车需要资金 加州大学洛杉矶分校帕萨罗天文台的四极飞行时间激光质谱仪 质谱学实验室。这是一个共享设施，由 化学与生物化学系(文理学院) 和精神病学和生物行为科学系(医学院 医学)，可供整个加州大学洛杉矶分校的研究和教学使用 进取号。加州大学洛杉矶分校的校园里没有这种类型的仪器。因为. 它们的灵敏度和选择性，即所谓的QTOF仪器已经得到了证明 对于快速和可靠地鉴定来自于 各种来源，包括从聚丙烯酰胺凝胶中去除的斑点 电泳图。该仪器将成为加州大学洛杉矶分校的中心功能 蛋白质组学倡议，目前正在建立中。一种QTOF测量仪 设计包含常规蛋白质所需的所有辅助组件 认同感，对于持续的生产力、成功和 越来越多的校园研究项目的竞争力。反思 这种用途的多样性，描述了对主要用户的研究 提供了仪器。

DESCRIPTION (provided by applicant): Funds are requested to purchase a hybrid quadrupole-time-of-flight laser mass spectrometer (QTOF) for the UCLA Pasarow Mass Spectrometry Laboratory. This is a shared facility jointly supported by the Department of Chemistry and Biochemistry (College of Letters and Sciences) and the Department of Psychiatry and Biobehavioral Sciences (School of Medicine) that is available to the entire UCLA campus research and teaching enterprise. There is no instrument of this type on the UCLA campus. Because of their sensitivity and selectivity, so-called QTOF instruments have been proven to be indispensable for the rapid and reliable identification of proteins from a variety of sources including spots excised from polyacrylamide gel electrophoretograms. This instrument will be a central feature of the UCLA proteomics initiative which is now being established. An instrument of QTOF design with all accessory components necessary for routine protein identification, is essential for the continued productivity, success and competitiveness of a growing number of campus research programs. Reflecting this diversity of use, descriptions of the research of the major users of the instrument are provided.