PHybrid Quadrupole/Orthogonal Time-of-Flight Mass Spec

描述（由申请人提供）：要求资金购买混合动力车 四极杆飞行时间激光质谱仪（QTOF），用于UCLA Pasarow 质谱实验室。这是一个共享的设施， 化学与生物化学系（文学与科学学院） 精神病学和生物行为科学系（精神病学和生物行为科学学院） 医学），提供给整个加州大学洛杉矶分校校园的研究和教学 企业.加州大学洛杉矶分校校园里没有这种类型的仪器。因为 它们的灵敏度和选择性，所谓的QTOF仪器已被证明 对于快速和可靠地鉴定蛋白质是不可缺少的， 多种来源，包括从聚丙烯酰胺凝胶中切下的斑点 电子照相。这种仪器将是加州大学洛杉矶分校的一个中心特征 目前正在建立的蛋白质组学倡议。QTOF仪器 具有常规蛋白质所需的所有辅助组件的设计 识别，对于持续的生产力，成功和 越来越多的校园研究项目的竞争力。反映 这种多样性的使用，描述的主要用户的研究， 提供了仪器。

DESCRIPTION (provided by applicant): Funds are requested to purchase a hybrid quadrupole-time-of-flight laser mass spectrometer (QTOF) for the UCLA Pasarow Mass Spectrometry Laboratory. This is a shared facility jointly supported by the Department of Chemistry and Biochemistry (College of Letters and Sciences) and the Department of Psychiatry and Biobehavioral Sciences (School of Medicine) that is available to the entire UCLA campus research and teaching enterprise. There is no instrument of this type on the UCLA campus. Because of their sensitivity and selectivity, so-called QTOF instruments have been proven to be indispensable for the rapid and reliable identification of proteins from a variety of sources including spots excised from polyacrylamide gel electrophoretograms. This instrument will be a central feature of the UCLA proteomics initiative which is now being established. An instrument of QTOF design with all accessory components necessary for routine protein identification, is essential for the continued productivity, success and competitiveness of a growing number of campus research programs. Reflecting this diversity of use, descriptions of the research of the major users of the instrument are provided.