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PURCHASE OF MASS SPECTROMETRIC INSTRUMENTATION

购买质谱仪器

基本信息

批准号：
6292230
负责人：
KYM Francis FAULL
金额：
$ 34.82万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
起止时间：
2001-05-01 至 2002-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6292230
关键词：
biomedical equipment purchase mass spectrometry

项目摘要

Funds are requested to purchase a new laser desorption mass spectrometer (LDMS) for the UCLA Pasarow Mass Spectrometry Laboratory. This is a shared facility jointly supported by the Department of Chemistry and Biochemistry (College of Letters and Sciences) and the Department of Psychiatry and Biobehavioral Sciences (School of Medicine) that is available to the entire UCLA campus research and teaching enterprise. The facility currently has one LDMS system. This is a PerSeptive Biosystems Voyager RP instrument which is the only LDMS on the UCLA campus. The work load for this instrument has grown since its acquisition in October 1994 such that instrument time is heavily booked. More importantly, this instrument has modest resolving and mass accuracy capabilities because it does not have the delayed ion extraction option. The absence of delayed ion extraction severely limits the usefulness of this instrument, particularly in the emerging proteome era when an increasing number of research groups need accurate mass assignments for protein and peptide identification and optimal resolution for the direct analysis of complex mixtures without having to resort to chromatography, and in the field of organic polymers where accurate mass measurements above 1,000 Daltons are becoming increasingly important. These capabilities are crucial for the continued productivity, success and competitiveness of several campus research programs in the biological and chemical sciences. Reflecting this diversity of use, descriptions of the research of the major users of LDMS are provided. In addition to the role it plays in these research programs, the facility handles numerous routine LDMS analyses, further substantiating the importance of this new instrument to this campus.

请求提供资金，为加州大学洛杉矶分校帕萨罗质谱实验室购买一台新的激光解吸质谱仪。这是一个由化学和生物化学系（文学与科学学院）和精神病学和生物行为科学系（医学院）共同支持的共享设施，可供整个UCLA校园研究和教学企业使用。该设施目前有一个LDMS系统。这是PerSeptive Biosystems Voyager RP仪器，是UCLA校园内唯一的LDMS。自1994年10月购置该仪器以来，其工作量有所增加，因此仪器时间被大量预订。更重要的是，该仪器具有适度的分辨率和质量精度能力，因为它没有延迟离子提取选项。延迟离子提取的缺乏严重限制了该仪器的有用性，特别是在新兴的蛋白质组时代，当越来越多的研究小组需要用于蛋白质和肽鉴定的精确质量分配和用于直接分析复杂混合物的最佳分辨率而不必诉诸色谱法时，以及在有机聚合物领域，其中精确质量测量高于1，000道尔顿变得越来越重要。这些能力对于生物和化学科学的几个校园研究项目的持续生产力，成功和竞争力至关重要。反映这种多样性的使用，LDMS的主要用户的研究的描述提供。除了在这些研究项目中发挥作用外，该设施还处理许多常规LDMS分析，进一步证实了这种新仪器对该校园的重要性。