HIGH-SPEED MRI FOR TUMOR INTERVENTIONS

描述(改编自申请人摘要)：本申请是一份 相互竞争的更新。最初的项目是关于新的快速磁共振 用于改进腹部肿瘤诊断的成像(MRI)技术。 在开发几种快速扫描方法方面取得了重大进展，这些方法 在屏气状态下生成高质量的T2加权腹部图像。焦点 这种相互竞争的更新是基于新的磁共振方法，这些方法超越了 肿瘤检测-指导肿瘤活检和其他介入 使用项目名称的程序已被修改以反映这一变化 对准焦点。该项目的目标是：1)设计和实现一个实时的、 为介入操作量身定做的交互式(RTI)MRI系统，2)开发 并将提供有用图像的新序列集成到RTI系统中 介入操作的对比；3)评估这一新的MR 对幻影和患者的干预系统。研究计划包括 多功能RTI MRI平台的实质性技术开发，研究 改进的MR捕获方法(例如，稳态自由进动、快速自旋 回声和彩色流)，并进行系统测试以验证 合成系统。一支拥有广泛技术和临床经验的研究团队 已经为这个项目汇集了专业知识。这些专业知识，以及 提供最先进的扫描仪，使斯坦福大学成为理想 开展这一项目所需的环境。

DESCRIPTION (Adapted from Applicant's Abstract): This application is a competing renewal. The original project concerned new fast magnetic resonance imaging (MRI) techniques for improved diagnosis of abdominal tumors. Significant progress was made in developing several fast-scan methods that produce high-quality T2-weighted abdominal images in a breath-hold. The focus of this competing renewal is on new MR methods that take the next step beyond tumor detection---the guidance of tumor biopsies and other interventional procedures using MR. The project title has been modified to reflect this change in focus. The aims of this project are to 1) design and implement a real-time, interactive (RTI) MRI system tailored for interventional procedures, 2) develop and integrate into the RTI system new sequences that provide useful image contrast for interventional procedures; and 3) evaluate this new MR interventional system on phantoms and patients. The research plan includes substantial technical development of a versatile RTI MRI platform, studies of improved MR acquisition methods (e.g., steady-state free precession, fast spin echo, and color flow), and systematic tests to validate the performance of the resultant system. A research team with extensive technical and clinical expertise has been assembled for this project. This expertise, along with the state-of-the-art scanners available, make Stanford University an ideal environment to carry out this project.