FLYBASE--A DROSOPHILA GENOMIC AND GENETIC DATABASE

果蝇是最重要的模式生物之一 现代生物学研究的许多方面，特别是 关于后生动物的生物学。比较研究表明， 证明了代谢、细胞和发育调节 网络在动物王国中是高度保守的，在许多 甚至是其他的类群。尤其是因为 果蝇的遗传学，黑腹果蝇， 果蝇物种，它已经引领了阐明许多 途径。在哺乳动物系统，特别是小鼠和人类， 完全基于果蝇 研究提供了。我们现在正处于这样一个阶段， 了解许多角色的生理作用，当 变异的，会导致人类疾病在许多情况下， 很大程度上来自于对这些基因的果蝇同源物的研究。采取 最大限度地利用信息的信息， 果蝇，都是为了果蝇，都是为了果蝇研究者 对于研究其他生物的科学家来说， 在飞行中被组织起来，并为广泛的生物界所接受。 这就是Flybase Consortium的作用。在这个应用程序中，FlyBase 要求5年的资金，继续努力提供 科学界的基本基因组和遗传信息， D.黑腹脂和其它drosolipid。这些信息将继续 可以通过Flybase万维网服务器轻松在线访问，镜像在 世界各地的几个网站。一个重要的新方面， 该项目是伯克利公共信息学团队的合并， 欧洲果蝇基因组计划与最初的FlyBase小组， 成为一个扩展的FlyBase联盟。这个新的FlyBase联盟将 为社区提供了一个完全统一的观点， 来自整个生物体和种群结构的遗传和基因组数据 下至序列级的信息。扩大后的项目将涉及 5个参与数据采集的站点之间的密切协调， 管理、组织和展示。的重要功能 研究社区将是一个重新组织的WWW服务器和一个 实现了各种新工具，包括许多基于Java的 图形显示。生物数据库需要解决的一个问题是 如何有效地相互连接。问题 互联是至关重要的，因为只有一小部分相关的生物学 都可以存放在一个仓库里FlyBase将继续在其 在促进互联互通方面发挥历史性的领导作用： 与其他团体合作，生产允许数据交换的软件， 数据库之间，一般通过促进共同努力， 满足科学界的需求。

The fruit fly, Drosophila, is one of the most important model organisms for many aspects of modern biological research, especially for issues regarding the biology of metazoa. Comparative studies have clearly demonstrated that the metabolic, cellular, and developmental regulatory networks are highly conserved within the animal kingdom, and in many cases, even to other taxa. Particularly because of the sophisticated genetics of the fruit fly, Drosophila melanogaster, the best-studied drosophilid species, it has led the way in elucidating many of the pathways. Much work in mammalian systems, especially the mouse and humans, has been completely based on the strong foundation that Drosophila research has provided. We are now at the point were we are beginning to understand the physiological roles of many of the roles that, when mutated, contribute to human disease. In many cases, the insights emerge largely from work on the Drosophila cognates of these genes. To take maximum advantage of the information of the information available for Drosophila, both for the Drosophila, both for the Drosophila researcher and for scientists working on other organisms, it is essential that data on the fly be organized and accessible to the broad biological community. This is the role of the Flybase Consortium. In this application, FlyBase requests 5 years of funding to continue its effort to provide the scientific community with the essential genomic and genetic information on D. melanogaster, and other drosolipids. This information will continue to be readily accessible on-line through the Flybase WWW server, mirrored at several sites throughout the world. An important new aspect of the project is the merger of the public informatics teams of the Berkeley and European Drosophila Genome Projects with the original FlyBase group to become an expanded FlyBase Consortium. This new FlyBase Consortium will provide the community with a completely unified view of all Drosophila genetic and genomic data from the whole organism and population structure information down to the sequence level. The expanded project will involve close coordination among the 5 participating sites of data capture, management, organization and presentation. Important features for the research community will be a re-organization of the WWW server and a implementation of a variety of new tools, including many Java-based graphical displays. One issue for the biological databases to address is how to interconnect effectively among themselves. Issue of interconnectivity are crucial, as only a fraction of the relevant biology can be housed in a single repository. FlyBase will continue in its historic leadership role in promoting interconnections: through working with other groups to produce software that will permit data exchange between databases, and generally through contributing to a joint effort to address the needs of the scientific community.